Evidence map›Paper›PMID 38888632›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Hyaluronic acid to manage radiotoxicities in gynecological cancer patients: a scoping review.

Letícia da Silva Ribeiro, Renata Cristina de Campos Pereira Silveira, Christiane Inocêncio Vasques, Amanda Gomes de Menêses, Paula Elaine Diniz Dos Reis, Elaine Barros Ferreira

Abstract readScoping Review
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Letícia da Silva RibeiroUniversity of Brasilia, School of Health Sciences, Nursing Department, Campus Darcy Ribeiro, Asa Norte, Brasília, DF, 70910-900, Brazil.ORCID http://orcid.org/0009-0000-7244-7213
Renata Cristina de Campos Pereira SilveiraUniversity of São Paulo, Ribeirão Preto College of Nursing, General and Specialized Nursing Department, WHO Collaborating Centre for Nursing Research Development, Bandeirantes Avenue, 3900, Campus-Monte Alegre, Ribeirão Preto, SP, 14040-902, Brazil.ORCID http://orcid.org/0000-0002-2883-3640
Christiane Inocêncio VasquesUniversity of Brasilia, School of Health Sciences, Nursing Department, Campus Darcy Ribeiro, Asa Norte, Brasília, DF, 70910-900, Brazil.ORCID http://orcid.org/0000-0001-9586-9486
Amanda Gomes de MenêsesUniversity of Brasilia, School of Health Sciences, Nursing Department, Campus Darcy Ribeiro, Asa Norte, Brasília, DF, 70910-900, Brazil.ORCID http://orcid.org/0000-0002-8658-7505
Paula Elaine Diniz Dos ReisUniversity of Brasilia, School of Health Sciences, Nursing Department, Campus Darcy Ribeiro, Asa Norte, Brasília, DF, 70910-900, Brazil.ORCID http://orcid.org/0000-0002-9782-3366
Elaine Barros FerreiraUniversity of Brasilia, School of Health Sciences, Nursing Department, Campus Darcy Ribeiro, Asa Norte, Brasília, DF, 70910-900, Brazil. elainebf@unb.br.ORCID http://orcid.org/0000-0003-0428-834X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to map the use of hyaluronic acid (HA) in preventing and controlling radiotoxicity in women with gynecological cancer undergoing radiotherapy.

methodsWe conducted a scoping review of eight electronic databases: CINAHL, Cochrane CENTRAL, LILACS, PubMed, Scopus, Embase, LIVIVO, and the Web of Science Core Collection. In addition, a grey literature search was performed using Google Scholar and ProQuest Dissertations & Theses Global. A manual search was also identified additional references. The search was conducted on May 18, 2023. We included primary studies, reviews, and guidelines that discussed the use of HA to prevent and manage the toxicities resulting from gynecological radiotherapy.

resultsEighteen studies were included in this scoping review, published between 2009 and 2022. There was heterogeneity in the use of HA, particularly in the method of application (moisturizing gel, vaginal ovules, spacer gel, and bladder instillations). Furthermore, the radiotoxicities varied among studies, encompassing, among others, vaginal atrophy, dryness, dyspareunia, telangiectasis, adhesions, vaginal stenosis, bleeding, hematuria, and bladder issues. Most studies addressed the potential benefits of HA in managing the signs and symptoms resulting from radiotherapy.

conclusionHA has been utilized in clinical practice, in various formulations, for managing signs and symptoms in patients with gynecological cancer undergoing radiotherapy. However, further studies are necessary to thoroughly investigate the most effective method of HA application and its effectiveness in managing radiotoxicity.

Indexed as

Genital Neoplasms, FemaleHyaluronic AcidRadiation InjuriesFemaleHumansHyaluronic AcidBrachytherapyGenital neoplasms, FemaleHyaluronic acidRadiotherapyReview

Identifiers

PMID38888632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.