Evidence map›Paper›PMID 38888546›Full record

ArticleThe journal of extra-corporeal technology2024

Designing an experimental method for assessing biocompatibility of circuit coatings using biomarkers for platelet activation during cardiopulmonary bypass.

Meghal Sancheti, Mitchell Rentschler, Charlotte Bolch, Weidang Li, Katelyn Necco, Thomas Rath, Mitra Esfandiarei, Nathaniel Darban

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of extra-corporeal technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meghal SanchetiArizona College of Osteopathic Medicine, Midwestern University, 19555 N. 59th Avenue, Glendale, AZ 85308, USA.
Mitchell RentschlerArizona College of Osteopathic Medicine, Midwestern University, 19555 N. 59th Avenue, Glendale, AZ 85308, USA.ORCID 0009-0002-9386-7211
Charlotte BolchOffice of Research & Sponsored Program, Midwestern University, 19555 N. 59th Avenue, Glendale, AZ 85308, USA.
Weidang LiCollege of Veterinary Medicine, Midwestern University, 19555 N. 59th Avenue, Glendale, AZ 85308, USA.
Katelyn NeccoCollege of Graduate Studies, Midwestern University, 19555 N. 59th Avenue, Glendale, AZ 85308, USA.
Thomas RathCollege of Health Sciences, Midwestern University, 19555 N. 59th Avenue, Glendale, AZ 85308, USA.
Mitra EsfandiareiCollege of Graduate Studies, Midwestern University, 19555 N. 59th Avenue, Glendale, AZ 85308, USA - College of Medicine Phoenix, University of Arizona, 19555 N. 59th Avenue, Glendale, AZ 85308, USA.
Nathaniel DarbanCollege of Health Sciences, Midwestern University, 19555 N. 59th Avenue, Glendale, AZ 85308, USA.

Funding

Midwestern University, Arizona College of Osteopathic Medicine KAS Research Fellowship, College of Health Science Intramural Funds
6 · The paper itself

Abstract

introductionCardiopulmonary bypass is an essential component of cardiothoracic surgeries. However, significant complications such as systemic inflammatory response syndrome (SIRS) resulting from cardiopulmonary bypass (CPB) are a common occurrence due to contact between circulating blood and foreign surfaces that leads to platelet activation. It is suggested that different available CPB circuit coatings can potentially reduce platelet activation. However, there have been no published evidence-based reports confirming these claims. In addition, there is no well-established protocol for studying platelet activation biomarkers during CPB in vitro in a laboratory setting.

methodsCPB was simulated in the laboratory using bovine blood in two different types of coated CPB circuits: Trillium

resultsThe biomarker values at 30 min and 55 min were compared to the base values at 5 min for each type of CPB circuit. The results of the means from all measured biomarkers showed data measurements that indicated no significant variability within each coating. All collected data points fell within ±2 SD of the means, which was considered acceptable variations across technical replicates.  Conclusion: In this study, we were able to establish an in vitro protocol in the laboratory setting that is precise and reliable with minimum intra-variability. This established protocol will allow for future studies in which different coated CPB circuits can be compared for their effectiveness in blocking platelet activation during the CPB.

Indexed as

BiomarkersCardiopulmonary BypassCoated Materials, BiocompatiblePlatelet ActivationAnimalsCattleMaterials TestingBiomarkersCoated Materials, BiocompatibleBiomarkersCardiopulmonary bypassCircuit coatingELISAPlatelet activationPlatelets

Identifiers

PMID38888546
PMCPMC11185148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.