ArticleMicrobiology spectrum2024
Glycine restores the sensitivity to antibiotics in multidrug-resistant bacteria.
Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Tuning the hydrophobicity of glycine ester throughRSC advances · 2026Article
- Dynamic reworking of marine diatom endometabolomes in response to temperature and a model bacterium.mSystems · 2026Article
- Antimicrobial Activity of Actinobacteria Isolated From Kratom (International journal of microbiology · 2026Article
- Comprehensive Characterization of Bioactive Properties in Extracts from Different Chilean Hop Ecotypes (Antioxidants (Basel, Switzerland) · 2025Article
- Synthesis, Characterization, and Potential Applications of Menthol-Amino Acid Ester Derivatives.Applied biochemistry and biotechnology · 2025Article
- Proteomic and metabolomic responses of priority bacterial pathogens to subinhibitory concentration of antibiotics.npj antimicrobials and resistance · 2025Article
- Chemotyping ofPlants (Basel, Switzerland) · 2025Article
- The Next Frontier: Unveiling Novel Approaches for Combating Multidrug-Resistant Bacteria.Pharmaceutical research · 2025Review
- Phenotypic and Molecular Characterization of Pyomelanin-ProducingMicroorganisms · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The management of infections caused by multiresistant bacteria has become of fundamental importance for any medical practice. Glycine is the most common and the simplest non-essential amino acid in humans. Glycine is very effective in improving health and supporting growth and wellbeing of humans and animals. Instead, for many bacteria, high concentrations of glycine induce lysis or deep morphological alterations. The effect of glycine on multidrug resistant (MDR) microorganisms has not yet been extensively researched. The present study was conducted 1) to establish the effect of glycine on different nosocomial pathogens isolated during routine diagnostic investigations; 2) to determine the minimum inhibitory concentration of glycine and the type of activity performed (bacteriostatic or bactericidal) on representative isolates; 3) to test the interaction between glycine and meropenem, cefiderocol, or colistin. The data reported here show a dose-dependent activity of glycine on bacteria and its bactericidal activity on MDR bacteria. Furthermore, we found that the action of glycine restores
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