Evidence map›Paper›PMID 38888299›Full record

ArticleChemical communications (Cambridge, England)2024

Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs.

Raoul Walther, Mahri Park, Nicola Ashman, Martin Welch, Jason S Carroll, David R Spring

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Raoul WaltherYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK.ORCID http://orcid.org/0000-0002-9833-6703
Mahri ParkYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK.ORCID http://orcid.org/0000-0003-3973-6026
Nicola AshmanYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK.ORCID http://orcid.org/0000-0003-4907-058X
Martin WelchDepartment of Biochemistry, University of Cambridge, CB2 1QW Cambridge, UK.
Jason S CarrollCancer Research UK Cambridge Institute, Robinson Way, CB2 0RE Cambridge, UK.ORCID http://orcid.org/0000-0003-3643-0080
David R SpringYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK.ORCID http://orcid.org/0000-0001-7355-2824

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe a versatile and tuneable thiol responsive linker system using thiovinylketones, which relies on the conjugate addition-elimination mechanism of Michael acceptors for the traceless release of therapeutics. In a proof-of-principle study, we translate our findings to exhibit potent thiol-cleavable antibiotic prodrugs and antibody-drug conjugates.

Indexed as

Drug LiberationImmunoconjugatesProdrugsSulfhydryl CompoundsAnti-Bacterial AgentsHumansKetonesMolecular StructureAnti-Bacterial AgentsImmunoconjugatesKetonesProdrugsSulfhydryl Compounds

Identifiers

PMID38888299
PMCPMC11223184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.