ArticleAnalytical chemistry2024
A Complementary Multitechnique Approach to Assess the Bias in Molecular Weight Determination of Lignin by Derivatization-Free Gel Permeation Chromatography.
Article in Analytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Benchmarking Fourier Transform Ion Cyclotron Resonance Mass Spectrometry against Conventional Methods for the Characterization of Solvent-Fractionated Kraft Lignin.Biomacromolecules · 2026Article
- Exploring Lignin Conformation in Organic and Deep Eutectic Solvents Using Small-Angle Neutron Scattering.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Advancing lignin analytics via elucidation of linkage progressions in lignin populations.Communications chemistry · 2025Article
- Engineering of Industrial Kraft Lignin: The Role of Esterification Methods in Lignin Nanoparticle Self-Assembly.Biomacromolecules · 2025Article
- Evaluation and Experiment of High-Strength Temperature- and Salt-Resistant Gel System.Gels (Basel, Switzerland) · 2025Article
- Synthesis and Characterization of PEG-Polymers · 2025Article
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Authors and funding
5 authors.
Funding
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Abstract
The growing interest in lignin valorization in the past decades calls for analytical techniques for lignin characterization, ranging from wet chemistry techniques to highly sophisticated chromatographic and spectroscopic methods. One of the key parameters to consider is the molecular weight profile of lignin, which is routinely determined by size-exclusion chromatography; however, this is by no means straightforward and is prone to being hampered by considerable errors. Our study expands the fundamental understanding of the bias-inducing mechanisms in gel permeation chromatography (GPC), the magnitude of error originating from using polystyrene standards for mass calibration, and an evaluation of the effects of the solvent and type of lignin on the observed bias. The developed partial least-squares (PLS) regression model for lignin-related monomers revealed that lignin is prone to association mainly via hydrogen bonding. This hypothesis was supported by functional group-based analysis of the bias as well as pulse field gradient (pfg) diffusion NMR spectroscopy of model compounds in THF-
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