Evidence map›Paper›PMID 38888067›Full record

ArticleCancer science2024

Zingiber officinale promotes autophagy and apoptosis in human oral cancer through the C/EBP homologous protein.

Hyun-Ji Kim, Ji-Ae Shin, Yeong-Geun Lee, Bohwan Jin, Won Woo Lee, Yosub Lee, Su-Jung Choi, Jung-Min Han, Min-Hye Ahn, Ji-Hoon Kim and 4 more

Abstract read
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In one paragraph

Article in Cancer science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Oncology reports · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hyun-Ji KimDepartment of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
Ji-Ae ShinDepartment of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Yeong-Geun LeeDepartment of Oriental Medicine Biotechnology, College of Life Science, Kyung Hee University, Yongin, Republic of Korea.
Bohwan JinLaboratory Animal Center, CHA University, Seongnam, Republic of Korea.
Won Woo LeeLaboratory Animal Center, CHA University, Seongnam, Republic of Korea.
Yosub LeeDepartment of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
Su-Jung ChoiDepartment of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
Jung-Min HanDepartment of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
Min-Hye AhnChemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.
Ji-Hoon KimDepartment of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
Dong-Guk ParkDepartment of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
Seong-Doo HongDepartment of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
Se-Chan KangDepartment of Oriental Medicine Biotechnology, College of Life Science, Kyung Hee University, Yongin, Republic of Korea.
Sung-Dae ChoDepartment of Oral Pathology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0001-8670-9579

Funding

Institute for Information and Communications Technology Promotion 2019R1A2C1085896Institute for Information and Communications Technology Promotion 2020R1C1C1005480
6 · The paper itself

Abstract

The rhizome of Zingiber officinale (Z. officinale), commonly known as ginger, has been characterized as a potential drug candidate due to its antitumor effects. However, the chemotherapeutic effect of ginger on human oral cancer remains poorly understood. In this study, we examined the effects of an ethanol extract of Z. officinale rhizomes (ZOE) on oral cancer and identified the components responsible for its pharmacological activity. ZOE exerts its inhibitory activity in oral cancer by inducing both autophagy and apoptosis simultaneously. Mechanistically, ZOE-induced autophagy and apoptosis in oral cancer are attributed to the reactive oxygen species (ROS)-mediated endoplasmic reticulum stress response. Additionally, we identified two active components of ZOE, 1-dehydro-6-gingerdione and 8-shogaol, which were sufficient to stimulate autophagy initiation and apoptosis induction by enhancing CHOP expression. These results suggest that ZOE and its two active components induce ROS generation, upregulate CHOP, initiate autophagy and apoptosis, and hold promising therapeutics against human oral cancer.

Indexed as

ApoptosisAutophagyEndoplasmic Reticulum StressMouth NeoplasmsPlant ExtractsReactive Oxygen SpeciesTranscription Factor CHOPZingiber officinaleAnimalsAntineoplastic Agents, PhytogenicCatecholsCell Line, TumorHumansMiceRhizomeXenograft Model Antitumor AssaysAntineoplastic Agents, PhytogenicCatecholsDDIT3 protein, humanPlant ExtractsReactive Oxygen SpeciesshogaolTranscription Factor CHOPapoptosisautophagyC/EBP homologous proteinoral cancerZingiber officinale

Identifiers

PMID38888067
PMCPMC11309930

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.