Evidence map›Paper›PMID 38887778›Full record

ArticleEuropean heart journal. Case reports2024

Acute aortic catastrophe caused by cardiovascular oncological manipulation by tyrosine kinase inhibitors with immune checkpoint blockades: a case report and literature review.

Sherif Sultan, Yogesh Acharya, Paul Donnellan, Niamh Hynes, Michael Kerin, Osama Soliman

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sherif SultanDepartment of Vascular and Endovascular Surgery, Western Vascular Institute, University Hospital Galway, University of Galway, Newcastle Rd, Galway H91 YR71, Ireland.ORCID https://orcid.org/0000-0001-8767-4929
Yogesh AcharyaDepartment of Vascular and Endovascular Surgery, Western Vascular Institute, University Hospital Galway, University of Galway, Newcastle Rd, Galway H91 YR71, Ireland.ORCID https://orcid.org/0000-0003-1829-5911
Paul DonnellanDepartment of Oncology, University Hospital Galway, University of Galway, Newcastle Rd, Galway H91 YR71, Ireland.ORCID https://orcid.org/0000-0003-3482-5062
Niamh HynesCORRIB-CURAM-Vascular Group, University of Galway, Newcastle Rd, Galway H91 YR71, Ireland.ORCID https://orcid.org/0000-0002-6133-3322
Michael KerinDepartment of Cardiovascular Oncology, University Hospital Galway, University of Galway, Newcastle Rd, Galway H91 YR71, Ireland.ORCID https://orcid.org/0000-0003-4164-5561
Osama SolimanCORRIB-CURAM-Vascular Group, University of Galway, Newcastle Rd, Galway H91 YR71, Ireland.ORCID https://orcid.org/0000-0003-0758-3539

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tyrosine kinase inhibitors targeting the vascular endothelial growth factor (VEGF) inhibitor pathway with immune checkpoint blockade have shown promising outcomes in managing metastatic renal cancer. However, they increase the risk of a person developing high blood pressure and cardiovascular complications. Case summary: In this study, we report the case of a 73-year-old woman on axitinib and pembrolizumab for her Stage 4 renal cell carcinoma. She presented with intractable chest pain and high systolic blood pressure, not responding to opiates. Her computed tomography angiography results showed an acute intra-mural haematoma with a rupture in the descending thoracic aorta. She underwent emergency thoracic endovascular aortic repair. Post-operatively, she recovered fully without any neurological or cardiovascular issues. Discussion: The severity of cardiovascular haemodynamic complications arising from the consumption of VEGF inhibitors and from immunotherapy and the lack of anti-hypertensive strategies to adequately manage such events require an unequivocal and urgent assessment of their cardiovascular safety. This case highlights the crucial role of cardiovascular oncology in managing such acute aortic catastrophes.

Indexed as

Acute aortic syndromeAortic intra-mural haematomaCase reportClear cell renal cell carcinomaImmune checkpoint blockersTyrosine kinase inhibitors

Identifiers

PMID38887778
PMCPMC11181861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.