Evidence map›Paper›PMID 38887668›Full record

ArticleNeurology research international2024

Increased Cerebrospinal Fluid Adenosine 5'-Triphosphate Levels in Patients with Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy.

Takamasa Nukui, Hideki Niimi, Tomohiro Hayashi, Nobuhiro Dougu, Mamoru Yamamoto, Ryoko Shibuya, Noriyuki Matsuda, Ryo Tanaka, Hiroaki Hirosawa, Risako Furuta and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology research international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The EGR1/ZFP36 axis governs glycosphingolipid metabolic reprogramming in monocyte-derived macrophages in guillain-barré syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Takamasa NukuiDepartment of Neurology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Hideki NiimiDepartment of Clinical Laboratory and Molecular Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan.
Tomohiro HayashiDepartment of Neurology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Nobuhiro DouguTakaoka City Hospital, Takaoka, Japan.
Mamoru YamamotoDepartment of Neurology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Ryoko ShibuyaDepartment of Neurology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Noriyuki MatsudaDepartment of Neurology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Ryo TanakaDepartment of Neurology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Hiroaki HirosawaDepartment of Neurology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Risako FurutaDepartment of Neurology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Taichi MitsuiDepartment of Neurology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Hiroki MaesakaDepartment of Neurology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Syuhei TakasawaDepartment of Neurology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Isao KitajimaDepartment of Clinical Laboratory and Molecular Pathology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan.
Yuji NakatsujiDepartment of Neurology, Faculty of Medicine, University of Toyama, Toyama, Japan.ORCID https://orcid.org/0000-0002-7708-1078

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Extracellular adenosine 5'-triphosphate (ATP) acts as a signaling molecule in the peripheral nerves, regulating myelination after nerve injury. The present study examined whether the cerebrospinal fluid (CSF) ATP levels in patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) are related to disease severity. Methods: CSF ATP levels in 13 patients with GBS and 18 patients with CIDP were compared with those in a control group of 16 patients with other neurological diseases (ONDs). In patients with CIDP, CSF ATP levels were compared before and after treatment. The correlations between CSF ATP levels and other factors, including clinical data and CSF protein levels, were also evaluated. Results: Median CSF ATP levels were significantly higher in patients with GBS and CIDP than in those with ONDs. When patients with CIDP were classified into two groups depending on their responsiveness to immunotherapy, median CSF ATP levels were significantly higher in good responders than in ONDs. CSF ATP levels tended to decrease after treatment in patients with CIDP. In patients with CIDP, there is a negative correlation between CSF ATP and CSF protein levels. Conclusions: CSF ATP levels were increased in patients with GBS and CIDP. In particular, CSF ATP levels tended to decrease following treatment in patients with CIDP. CSF ATP levels may be useful biomarkers for the diagnosis or monitoring of therapeutic effects in patients with GBS and CIDP.

Identifiers

PMID38887668
PMCPMC11182687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.