Evidence map›Paper›PMID 38887635›Full record

ReviewRSC advances2024

Chitosan alchemy: transforming tissue engineering and wound healing.

Sheersha Pramanik, Akanksha Aggarwal, Ammar Kadi, Majid Alhomrani, Abdulhakeem S Alamri, Walaa F Alsanie, Kanchan Koul, A Deepak, Stefano Bellucci

Abstract readReview
In one paragraph

Review in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Freeze-Dried CS/PVP/PVA Composite Scaffolds Doped with Curcumin and SiOInternational journal of molecular sciences · 2026
    Article
  6. Article
  7. Black Sea-Derived Biomaterials for Wound-Healing Applications.International journal of molecular sciences · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Polysaccharides self-healing hydrogel for skin regeneration.Journal of pharmaceutical analysis · 2026
    Review
  13. Review
  14. Dextran-based stimuli-responsive hydrogels for smart dressings in wound healing.Journal of materials science. Materials in medicine · 2026
    Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Fungal-Derived Chitosan fromMaterials (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sheersha PramanikDepartment of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras Chennai 600036 Tamil Nadu India.ORCID https://orcid.org/0000-0001-6912-937X
Akanksha AggarwalDepartment of Biotechnology, Indian Institute of Technology Hyderabad Kandi Sangareddy Telangana 502284 India.
Ammar KadiDepartment of Food and Biotechnology, South Ural State University Chelyabinsk 454080 Russia.
Majid AlhomraniDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University Taif Saudi Arabia.
Abdulhakeem S AlamriDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University Taif Saudi Arabia.
Walaa F AlsanieDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University Taif Saudi Arabia.
Kanchan KoulDepartment of Physiotherapy, Jain School of Sports Education and Research, Jain University Bangalore Karnataka 560069 India.ORCID https://orcid.org/0000-0003-3241-6599
A DeepakSaveetha Institute of Medical and Technical Sciences, Saveetha School of Engineering Chennai Tamil Nadu 600128 India deepakarun@saveetha.com.
Stefano Bellucci7INFN-Laboratori Nazionali di Frascati Via E. Fermi 54 00044 Frascati Italy stefano.bellucci@lnf.infn.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chitosan, a biopolymer acquired from chitin, has emerged as a versatile and favorable material in the domain of tissue engineering and wound healing. Its biocompatibility, biodegradability, and antimicrobial characteristics make it a suitable candidate for these applications. In tissue engineering, chitosan-based formulations have garnered substantial attention as they have the ability to mimic the extracellular matrix, furnishing an optimal microenvironment for cell adhesion, proliferation, and differentiation. In the realm of wound healing, chitosan-based dressings have revealed exceptional characteristics. They maintain a moist wound environment, expedite wound closure, and prevent infections. These formulations provide controlled release mechanisms, assuring sustained delivery of bioactive molecules to the wound area. Chitosan's immunomodulatory properties have also been investigated to govern the inflammatory reaction during wound healing, fostering a balanced healing procedure. In summary, recent progress in chitosan-based formulations portrays a substantial stride in tissue engineering and wound healing. These innovative approaches hold great promise for enhancing patient outcomes, diminishing healing times, and minimizing complications in clinical settings. Continued research and development in this field are anticipated to lead to even more sophisticated chitosan-based formulations for tissue repair and wound management. The integration of chitosan with emergent technologies emphasizes its potential as a cornerstone in the future of regenerative medicine and wound care. Initially, this review provides an outline of sources and unique properties of chitosan, followed by recent signs of progress in chitosan-based formulations for tissue engineering and wound healing, underscoring their potential and innovative strategies.

Identifiers

PMID38887635
PMCPMC11180996

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.