Evidence map›Paper›PMID 38887581›Full record

ArticleBeilstein journal of organic chemistry2024

Bismuth(III) triflate: an economical and environmentally friendly catalyst for the Nazarov reaction.

Manoel Trindade Rodrigues, Aline Silva Barroso de Oliveira, Ralph C Gomes, Amanda Soares Hirata, Lucas A Zeoly, Hugo Santos, João Arantes, Catarina Sofia Mateus Reis-Silva, João Agostinho Machado-Neto, Leticia Veras Costa-Lotufo and 1 more

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In one paragraph

Article in Beilstein journal of organic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Manoel Trindade RodriguesInstitute of Chemistry, Universidade Estadual de Campinas, PO Box 6154, 13083-970 Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-9230-5642
Aline Silva Barroso de OliveiraInstitute of Chemistry, Universidade Estadual de Campinas, PO Box 6154, 13083-970 Campinas, São Paulo, Brazil.
Ralph C GomesInstitute of Chemistry, Universidade Estadual de Campinas, PO Box 6154, 13083-970 Campinas, São Paulo, Brazil.
Amanda Soares HirataDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, Brazil.ORCID https://orcid.org/0000-0001-8480-9875
Lucas A ZeolyInstitute of Chemistry, Universidade Estadual de Campinas, PO Box 6154, 13083-970 Campinas, São Paulo, Brazil.
Hugo SantosInstitute of Chemistry, Universidade Estadual de Campinas, PO Box 6154, 13083-970 Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-7411-5180
João ArantesInstitute of Chemistry, Universidade Estadual de Campinas, PO Box 6154, 13083-970 Campinas, São Paulo, Brazil.
Catarina Sofia Mateus Reis-SilvaDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, Brazil.
João Agostinho Machado-NetoDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, Brazil.
Leticia Veras Costa-LotufoDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, Brazil.
Fernando CoelhoInstitute of Chemistry, Universidade Estadual de Campinas, PO Box 6154, 13083-970 Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-1800-1549

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe the use of bismuth(III) triflate as an efficient and environmentally friendly catalyst for the Nazarov reaction of aryl vinyl ketones, leading to the synthesis of 3-aryl-2-ethoxycarbonyl-1-indanones and 3-aryl-1-indanones. By changing the temperature and reaction time, it was possible to modulate the reactivity, allowing the synthesis of two distinct product classes (3-aryl-2-ethoxycarbonyl-1-indanones and 3-aryl-1-indanones) in good to excellent yield. The reaction did not require additives and was insensitive to both air and moisture. Preliminary biological evaluation of some indanones showed a promising profile against some human cancer line cells.

Indexed as

bismuthcatalysisheterocyclesindanonesNazarov reaction

Identifiers

PMID38887581
PMCPMC11181232

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.