ArticleDiabetologia1985
Stimulation of insulin release by an organic calcium agonist.
Article in Diabetologia, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 46 citations in OpenAlex.
- A microwave-assisted bismuth nitrate-catalyzed unique route toward 1,4-dihydropyridines.Molecules (Basel, Switzerland) · 2012Article
- Hantzsch synthesis of 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(o-methoxyphenyl)-1,4-dihydropyridine; a novel cyclisation leading to an unusual formation of 1-amino-2-methoxy-carbonyl-3,5-bis(o-methoxyphenyl)-4-oxa-cyclohexan-1-ene.Molecules (Basel, Switzerland) · 2007Article
- Review
- Review
- Effect of nicardipine on insulin secretion, glucose and lipid metabolism in hypertensive, non-insulin dependent diabetics.European journal of clinical pharmacology · 1989Article
- Evidence for two calcium currents in insulin-secreting cells.Pflugers Archiv : European journal of physiology · 1988Article
- Antibodies to an alpha subunit of skeletal muscle calcium channels regulate parathyroid cell secretion.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Different insulin-secretory responses to calcium-channel blockers in islets of lean and obese (ob/ob) mice.The Biochemical journal · 1988Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The calcium-agonist 4-[2-(difluoromethoxy)phenyl]-1,4,5,7-tetrahydro-2-methyl-5-oxo-fu ro[ 3,4-b]pyridine-3-carboxylic acid ethylester provoked, in the 1.0-100 mumol/l range, a dose-related increase of glucose-stimulated insulin release by rat pancreatic islets. A fixed concentration of the drug (50 mumol/l) caused a shift to the left of the sigmoidal curve relating insulin output to glucose concentration. The drug failed to affect insulin release evoked, in the absence of Ca2+, by the combination of Ba2+ and theophylline. The enhancing action of the calcium-agonist upon insulin release was rapid and sustained, and coincided with stimulation of both 45Ca net uptake and 45Ca efflux, the latter phenomenon being abolished in the absence of extracellular Ca2+. It is concluded that the gating of Ca-channels, as presumably provoked by the calcium-agonist, simulates the stimulant action of glucose upon both Ca influx into and insulin release from the pancreatic islets.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.