Evidence map›Paper›PMID 38887520›Full record

ReviewFrontiers in cell and developmental biology2024

Progress in the study of autophagy-related proteins affecting resistance to chemotherapeutic drugs in leukemia.

Meng Li, Jing Li, Shiming Zhang, Linghan Zhou, Yuanyuan Zhu, Shen Li, Qiong Li, Junjie Wang, Ruipeng Song

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Oxidative Phosphorylation and Fatty Acid Oxidation Are Central to Mitochondrial Metabolism Rewiring in CML Stem/Progenitor Cell Survival.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meng Li *Nursing Department, The Third People's Hospital of Henan Province, Zhengzhou, China.
Jing Li *Department of Pathophysiology, Sepsis Translational Medicine Key Laboratory of Hunan Province, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Shiming Zhang *Clinical College, Xiamen Medical University, Xiamen, Fujian, China.
Linghan ZhouNursing Department, The Third People's Hospital of Henan Province, Zhengzhou, China.
Yuanyuan ZhuNursing Department, The Third People's Hospital of Henan Province, Zhengzhou, China.
Shen LiRehabilitation Department, Henan Institute of Massage, Luoyang, Henan, China.
Qiong LiNursing Department, Xinxiang Medical University, Xinxiang, China.
Junjie WangPlastic Surgery, The Third People's Hospital of Henan Province, Zhengzhou, China.
Ruipeng SongEndocrinology Department, The Third People's Hospital of Henan Province, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leukemia is a life-threatening malignant tumor of the hematopoietic system. Currently, the main treatment modalities are chemotherapy and hematopoietic stem cell transplantation. However, increased drug resistance due to decreased sensitivity of leukemia cells to chemotherapeutic drugs presents a major challenge in current treatments. Autophagy-associated proteins involved in autophagy initiation have now been shown to be involved in the development of various types of leukemia cells and are associated with drug resistance. Therefore, this review will explore the roles of autophagy-related proteins involved in four key autophagic processes: induction of autophagy and phagophore formation, phagophore extension, and autophagosome formation, on the development of various types of leukemias as well as drug resistance. Autophagy may become a promising therapeutic target for treating leukemia.

Indexed as

autophagy-associated proteinschemotherapeutic drugsdrug toleranceleukaemiareview

Identifiers

PMID38887520
PMCPMC11180896

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.