Evidence map›Paper›PMID 38887373›Full record

ArticleOncoimmunology2024

ALCAM-mediated cDC1 CD8 T cells interactions are suppressed in advanced lung tumors.

Luciano G Morosi, Giulia M Piperno, Lucía López, Roberto Amadio, Sonal Joshi, Alessandra Rustighi, Giannino Del Sal, Federica Benvenuti

Abstract read
In one paragraph

Article in Oncoimmunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luciano G MorosiCellular Immunology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Giulia M PipernoCellular Immunology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Lucía LópezCellular Immunology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Roberto AmadioCellular Immunology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Sonal JoshiCellular Immunology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Alessandra RustighiDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Giannino Del SalDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Federica BenvenutiCellular Immunology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.ORCID 0000-0002-1908-8052

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional type 1 dendritic cells (cDC1) are critical regulators of anti-tumoral T-cell responses. The structure and abundance of intercellular contacts between cDC1 and CD8 T cells in cancer tissues is important to determine the outcome of the T-cell response. However, the molecular determinants controlling the stability of cDC1-CD8 interactions during cancer progression remain poorly investigated. Here, we generated a genetic model of non-small cell lung cancer crossed to a fluorescent cDC1 reporter (KP-XCR1

Indexed as

Activated-Leukocyte Cell Adhesion MoleculeAntigens, CDCarcinoma, Non-Small-Cell LungCD8-Positive T-LymphocytesDendritic CellsLung NeoplasmsAnimalsCell Adhesion Molecules, NeuronalCell CommunicationHumansMiceActivated-Leukocyte Cell Adhesion MoleculeALCAM protein, humanAntigens, CDCell Adhesion Molecules, NeuronalALCAMcDC1immunological synapselung cancerNSCLC

Identifiers

PMID38887373
PMCPMC11181928

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.