Evidence map›Paper›PMID 38887372›Full record

ArticleOncoimmunology2024

CD28-CD57+ T cells from head and neck cancer patients produce high levels of cytotoxic granules and type II interferon but are not senescent.

Brendan L C Kinney, Brianna Brammer, Vikash Kansal, Connor J Parrish, Haydn T Kissick, Yuan Liu, Nabil F Saba, Zachary S Buchwald, Mark W El-Deiry, Mihir R Patel and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Early-Phase Trial of IAP Antagonist Tolinapant and Definitive Radiation in Cisplatin-Ineligible Patients with Advanced Head and Neck Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  8. CD8Current oncology (Toronto, Ont.) · 2025
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Brendan L C KinneyDepartment of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.
Brianna BrammerDepartment of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.
Vikash KansalDepartment of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.
Connor J ParrishSchool of Medicine, St. Louis University School of Medicine, St. Louis, MO, USA.
Haydn T KissickWinship Cancer Institute, Emory University, Atlanta, GA, USA.
Yuan LiuWinship Cancer Institute, Emory University, Atlanta, GA, USA.
Nabil F SabaWinship Cancer Institute, Emory University, Atlanta, GA, USA.
Zachary S BuchwaldDepartment of Radiation Oncology, Emory University, Atlanta, GA, USA.
Mark W El-DeiryDepartment of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.
Mihir R PatelDepartment of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.
Brian J BoyceDepartment of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.
Azeem S KakaDepartment of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.
Jennifer H GrossDepartment of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.
H Michael BaddourDepartment of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.
Amy Y ChenDepartment of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.
Nicole C SchmittDepartment of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.ORCID 0000-0002-0571-3531

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
NCI NIH HHS P30 CA138292
6 · The paper itself

Abstract

T lymphocytes expressing CD57 and lacking costimulatory receptors CD27/CD28 have been reported to accumulate with aging, chronic infection, and cancer. These cells are described as senescent, with inability to proliferate but enhanced cytolytic and cytokine-producing capacity. However, robust functional studies on these cells taken directly from cancer patients are lacking. We isolated these T cells and their CD27/28+ counterparts from blood and tumor samples of 50 patients with previously untreated head and neck cancer. Functional studies confirmed that these cells have enhanced ability to degranulate and produce IFN-γ. They also retain the ability to proliferate, thus are not senescent. These data suggest that CD27/28-CD57+ CD8+ T cells are a subset of highly differentiated, CD45RA+ effector memory (T

Indexed as

CD28 AntigensCD57 AntigensCD8-Positive T-LymphocytesHead and Neck NeoplasmsInterferon-gammaAdultAgedAged, 80 and overCell ProliferationCellular SenescenceFemaleHumansMaleMiddle AgedCD28 AntigensCD57 AntigensInterferon-gammaCD28CD57cellular senescencecostimulationhead and neck cancerKLRG1TEMRA cells

Identifiers

PMID38887372
PMCPMC11181932

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.