Evidence map›Paper›PMID 38887367›Full record

ReviewFrontiers in neuroscience2024

Molecular mechanisms and therapeutic possibilities of short-chain fatty acids in posttraumatic stress disorder patients: a mini-review.

Pavlo Petakh, Khrystyna Duve, Valentyn Oksenych, Payam Behzadi, Oleksandr Kamyshnyi

Abstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026
    Review
  9. Review
  10. Article
  11. Observational
  12. Review
  13. Review
  14. Review
  15. War, diet, and PTSD in Ukrainian youth.Scientific reports · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pavlo PetakhDepartment of Biochemistry and Pharmacology, Uzhhorod National University, Uzhhorod, Ukraine.
Khrystyna DuveDepartment of Neurology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Valentyn OksenychBroegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
Payam BehzadiDepartment of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.
Oleksandr KamyshnyiDepartment of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This mini-review explores the role of short-chain fatty acids (SCFAs) in posttraumatic stress disorder (PTSD). Highlighting the microbiota-gut-brain axis, this study investigated the bidirectional communication between the gut microbiome and mental health. SCFAs, byproducts of gut microbial fermentation, have been examined for their potential impact on PTSD, with a focus on molecular mechanisms and therapeutic interventions. This review discusses changes in SCFA levels and bacterial profiles in individuals with PTSD, emphasizing the need for further research. Promising outcomes from clinical trials using probiotics and fermented formulations suggest potential avenues for PTSD management. Future directions involve establishing comprehensive human cohorts, integrating multiomics data, and employing advanced computational methods, with the goal of deepening our understanding of the role of SCFAs in PTSD and exploring microbiota-targeted interventions.

Indexed as

acetatebutyrategut microbiomeposttraumatic stress disorderprobioticpropionateSCFAstress

Identifiers

PMID38887367
PMCPMC11182003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.