Evidence map›Paper›PMID 38887342›Full record

ReviewCureus2024

The Neurological Implications of COVID-19: A Comprehensive Narrative Review.

Ithamar Cheyne, Venmanassery Sreejan Gopinath, Neeharika Muppa, Angel Emanuel Armas, Maria Sophia Gil Agurto, Sai Abhigna Akula, Shubhangi Nagpal, Muhammad Sheraz Yousaf, Ali Haider

Abstract readReview
In one paragraph

Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ithamar CheyneCritical Care, Medical University of Warsaw, Warsaw, POL.
Venmanassery Sreejan GopinathInternal Medicine, University Hospital Coventry and Warwickshire, Coventry, GBR.
Neeharika MuppaSchool of Medicine, St. George's University, St. George's, GRD.
Angel Emanuel ArmasInternal Medicine, Cardiac Arrhythmia Service, Harvard Medical School, Boston, USA.
Maria Sophia Gil AgurtoInternal Medicine, School of Medicine, San Martin de Porres University, Lima, PER.
Sai Abhigna AkulaInternal Medicine, School of Medicine, St. George's University, St. George's, GRD.
Shubhangi NagpalInternal Medicine, Guru Gobind Singh Government Hospital, New Delhi, IND.
Muhammad Sheraz YousafInternal Medicine, Medstar Health, Baltimore, USA.
Ali HaiderAllied Health Sciences, The University of Lahore, Gujrat Campus, Gujrat, PAK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 revealed a huge number of problems as well as discoveries in medicine, notably, regarding the effects of the virus on the central nervous system (CNS) and peripheral nervous system (PNS). This paper is a narrative review that takes a deep dive into the complex interactions between COVID-19 and the NS. Therefore, this paper explains the broad range of neurological manifestations and neurodegenerative diseases caused by the virus. It carefully considers the routes through which SARS-CoV-2 reaches the NS, including the olfactory system and of course, the hematogenous route, which are also covered when discussing the virus's direct and indirect mechanisms of neuropathogenesis. Besides neurological pathologies such as stroke, encephalitis, Guillain-Barré syndrome, Parkinson's disease, and multiple sclerosis, the focus area is also given to the challenges of making diagnosis, treatment, and management of these conditions during the pandemic. The review also examines the strategic and interventional approaches utilized to prevent these disorders, as well as the ACE2 receptors implicated in the mediation of neurological effects caused by COVID-19. This detailed overview, which combines research outputs with case data, is directed at tackling this pandemic challenge, with a view toward better patient care and outcomes in the future.

Indexed as

covid-19encephalitisguillain-barre syndromeneuroimmunologyneuroinvasionneurological complicationsneuropathogenesisparkinson's diseasesars-cov-2treatment strategies

Identifiers

PMID38887342
PMCPMC11181960

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.