Evidence map›Paper›PMID 38887331›Full record

ArticleCureus2024

Survival of Metastatic Human Papillomavirus (HPV)-Related Head and Neck Cancer Receiving Platinum-Based Triplet Induction Chemotherapy and Relevance of Circulating Tumor HPV DNA.

Hirotaka Eguchi, Yukinori Takenaka, Hidenori Tanaka, Motoyuki Suzuki, Masafumi Horie, Haruka Kanai, Yuji Seo, Kazuhiko Ogawa, Shinichi Yachida, Hidenori Inohara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hirotaka EguchiHead and Neck Surgery, Osaka University, Suita, JPN.
Yukinori TakenakaHead and Neck Surgery, Osaka University, Suita, JPN.
Hidenori TanakaHead and Neck Surgery, Osaka University, Suita, JPN.
Motoyuki SuzukiHead and Neck Surgery, Osaka University, Suita, JPN.
Masafumi HorieBasic Sciences, Osaka University, Suita, JPN.
Haruka KanaiHead and Neck Surgery, Osaka University, Suita, JPN.
Yuji SeoRadiation Oncology, Osaka University, Suita, JPN.
Kazuhiko OgawaRadiation Oncology, Osaka University, Suita, JPN.
Shinichi YachidaBasic Sciences, Osaka University, Suita, JPN.
Hidenori InoharaOtorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives We aimed to examine the effectiveness of platinum-based triplet induction chemotherapy in metastatic squamous cell carcinoma of the head and neck (HNSCC) at diagnosis in terms of tumor human papillomavirus (HPV) status and the clinical relevance of circulating tumor HPV DNA (ctHPVDNA) during induction chemotherapy. Methods  Twenty-one patients were included. ctHPVDNA was longitudinally quantified using optimized digital PCR in a subset of patients. Results HPV-related HNSCC patients (N=7) had a significantly better response to induction chemotherapy than HPV-unrelated HNSCC patients (N=14) (complete or partial response rate, 100% vs. 36%,

Indexed as

circulating tumor dna (ctdna)human papilloma virusmetastasisoropharynx cancersquamous cell carcinoma

Identifiers

PMID38887331
PMCPMC11181740

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.