Evidence map›Paper›PMID 38887294›Full record

ArticleFrontiers in immunology2024

Regulatory and memory T lymphocytes infiltrating prostate tumors predict long term clinical outcomes.

Oscar Eduardo Molina, Hélène LaRue, David Simonyan, Hélène Hovington, Benjamin Vittrant, Bernard Têtu, Vincent Fradet, Louis Lacombe, Alain Bergeron, Yves Fradet

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. CD4Trends in cancer · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Oscar Eduardo MolinaAxe oncologie, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Hélène LaRueAxe oncologie, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
David SimonyanPlateforme de recherche clinique et évaluative, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Hélène HovingtonAxe oncologie, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Benjamin VittrantAxe oncologie, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Bernard TêtuAxe oncologie, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Vincent FradetAxe oncologie, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Louis LacombeAxe oncologie, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Alain BergeronAxe oncologie, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Yves FradetAxe oncologie, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The localization, density but mostly the phenotype of tumor infiltrating lymphocytes (TIL) provide important information on the initial interaction between the host immune system and the tumor. Our objective was to assess the prognostic significance of T (CD3 Methods: Immunohistochemistry (IHC) was used to assess the infiltration of CD3 Results: TIL subtypes were present at different densities in the tumor, tumor margin and adjacent normal-like epithelium, but their density and phenotype in the tumor area were the most predictive of clinical outcomes. In multivariate analyses, a high density of T Conclusion: These results show that the proportion of T

Indexed as

Lymphocytes, Tumor-InfiltratingMemory T CellsProstatic NeoplasmsT-Lymphocytes, RegulatoryAgedBiomarkers, TumorForkhead Transcription FactorsHumansMaleMiddle AgedPrognosisBiomarkers, TumorForkhead Transcription FactorsFOXP3 protein, humanclinical outcomesimmunohistochemistrylymphocytesmemory T cellsprognosis biomarkersprostate cancerregulatory T cellstumor immune cell infiltration

Identifiers

PMID38887294
PMCPMC11180786

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.