Evidence map›Paper›PMID 38887269›Full record

ArticleFrontiers in endocrinology2024

Causal relationship between T2DM microvascular complications and gut microbiota: a Mendelian randomization study.

Junping Zhang, Zilu Yu, Shanshan Li, Qingfang Zhang, Wen Chen, Jingying Wang, Shasha He, Ying Liu, Shen Chen, Jixiong Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Oral Microbiome and Constipation: A Causal Link Revealed by Mendelian Randomization.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Junping Zhang *Department of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, China.
Zilu Yu *Queen Mary School, Medical College, Nanchang University, Nanchang, China.
Shanshan Li *Department of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, China.
Qingfang ZhangQueen Mary School, Medical College, Nanchang University, Nanchang, China.
Wen ChenDepartment of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, China.
Jingying WangDepartment of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, China.
Shasha HeDepartment of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, China.
Ying LiuDepartment of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, China.
Shen ChenDepartment of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, China.
Jixiong XuDepartment of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gowing number of studies have demonstrated the association between gut microbiome and T2DM microvascular complications, however the causal relationship remains unclear. Therefore, we using the Mendelian randomization (MR) approach to investigate this causal relation. Methods: Using gut microbiome data from the International MiBioGen Consortium genome-wide association study (GWAS) and T2DM microvascular complications data from the FinnGen Consortium GWAS to perform MR analyses. Single nucleotide polymorphisms (SNPs) were selected as instrumental variables (IVs), the inverse variance weighting (IVW) method was used as the primary analysis method, and the results were tested for heterogeneity and horizontal pleiotropy. Results: Our research identified that there are 5 known microbial species and 2 unknown microbial species in the gut microbiome that were causally related to T2DM retinopathy. Besides, three and seven known microbial species causal relationships between the gut microbiome and T2DM neuropathy and T2DM nephropathy, respectively. Conclusions: Using MR methods, we demonstrated the causal relationship between gut microbiome and microvascular complications in T2DM, providing a new strategy for the prevention and treatment of it.

Indexed as

Diabetes Mellitus, Type 2Gastrointestinal MicrobiomeGenome-Wide Association StudyMendelian Randomization AnalysisPolymorphism, Single NucleotideHumansMicrovesselsgut microbiomeMendelian randomization studynephropathyneuropathyretinopathytype 2 diabetes

Identifiers

PMID38887269
PMCPMC11180823

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.