Evidence map›Paper›PMID 38887268›Full record

ArticleFrontiers in endocrinology2024

Deficiency of glucocorticoid receptor in bone marrow adipocytes has mild effects on bone and hematopoiesis but does not influence expansion of marrow adiposity with caloric restriction.

Rebecca L Schill, Jack Visser, Mariah L Ashby, Ziru Li, Kenneth T Lewis, Antonio Morales-Hernandez, Keegan S Hoose, Jessica N Maung, Romina M Uranga, Hadla Hariri and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rebecca L SchillDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Jack VisserDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Mariah L AshbyDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Ziru LiDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Kenneth T LewisDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Antonio Morales-HernandezDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, United States.
Keegan S HooseDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Jessica N MaungDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Romina M UrangaDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Hadla HaririDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Isabel D K HermsmeyerDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Hiroyuki MoriDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Ormond A MacDougaldDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Unlike white adipose tissue depots, bone marrow adipose tissue (BMAT) expands during caloric restriction (CR). Although mechanisms for BMAT expansion remain unclear, prior research suggested an intermediary role for increased circulating glucocorticoids. Methods: In this study, we utilized a recently described mouse model ( Results: Mice lacking GR in BMAds ( Discussion: In conclusion, our data suggest that eliminating GR from BMAd has minor effects on bone and hematopoiesis, and does not impair BMAT accumulation during CR.

Indexed as

AdipocytesAdiposityBone MarrowCaloric RestrictionHematopoiesisReceptors, GlucocorticoidAdipose TissueAnimalsBone and BonesFemaleMaleMiceMice, Inbred C57BLMice, KnockoutNR3C1 protein, mouseReceptors, Glucocorticoidbonebone marrow adipose tissue (BMAT)caloric restriction (CR)glucocorticoid receptor (GR)glucocorticoids (GC)hematopoiesis

Identifiers

PMID38887268
PMCPMC11180776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.