Evidence map›Paper›PMID 38887056›Full record

ArticleJournal of movement disorders2024

Association Between Exposure to Particulate Matter and the Incidence of Parkinson's Disease: A Nationwide Cohort Study in Taiwan.

Ting-Bin Chen, Chih-Sung Liang, Ching-Mao Chang, Cheng-Chia Yang, Hwa-Lung Yu, Yuh-Shen Wu, Winn-Jung Huang, I-Ju Tsai, Yuan-Horng Yan, Cheng-Yu Wei and 1 more

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In one paragraph

Article in Journal of movement disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. A PLAN to address the Parkinson pandemic.Journal of Parkinson's disease · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ting-Bin ChenDepartment of Neurology, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan.
Chih-Sung LiangDepartment of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Ching-Mao ChangCenter for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Cheng-Chia YangDepartment of Healthcare Administration, Asia University, Taichung, Taiwan.
Hwa-Lung YuDepartment of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan.
Yuh-Shen WuDepartment of Safety, Health, and Environmental Engineering, Hung Kuang University, Taichung, Taiwan.
Winn-Jung HuangDepartment of Safety, Health, and Environmental Engineering, Hung Kuang University, Taichung, Taiwan.
I-Ju TsaiDepartment of Medical Research, Kuang Tien General Hospital, Taichung, Taiwan.
Yuan-Horng YanDepartment of Medical Research, Kuang Tien General Hospital, Taichung, Taiwan.
Cheng-Yu WeiDepartment of Exercise and Health Promotion, College of Kinesiology and Health, Chinese Culture University, Taipei, Taiwan.
Chun-Pai YangDepartment of Neurology, Kuang Tien General Hospital, Taichung, Taiwan.

Funding

Hungkuang University HK-KTOH-109-05Kuang Tien General Hospital
6 · The paper itself

Abstract

objectiveEmerging evidence suggests that air pollution exposure may increase the risk of Parkinson's disease (PD). We aimed to investigate the association between exposure to fine particulate matter (PM2.5) and the risk of incident PD nationwide.

methodsWe utilized data from the Taiwan National Health Insurance Research Database, which is spatiotemporally linked with air quality data from the Taiwan Environmental Protection Administration website. The study population consisted of participants who were followed from the index date (January 1, 2005) until the occurrence of PD or the end of the study period (December 31, 2017). Participants who were diagnosed with PD before the index date were excluded. To evaluate the association between exposure to PM2.5 and incident PD risk, we employed Cox regression to estimate the hazard ratio and 95% confidence interval (CI).

resultsA total of 454,583 participants were included, with a mean (standard deviation) age of 63.1 (9.9) years and a male proportion of 50%. Over a mean follow-up period of 11.1 (3.6) years, 4% of the participants (n = 18,862) developed PD. We observed a significant positive association between PM2.5 exposure and the risk of PD, with a hazard ratio of 1.22 (95% CI, 1.20-1.23) per interquartile range increase in exposure (10.17 μg/m3) when adjusting for both SO2 and NO2.

conclusionWe provide further evidence of an association between PM2.5 exposure and the risk of PD. These findings underscore the urgent need for public health policies aimed at reducing ambient air pollution and its potential impact on PD.

Indexed as

Air pollutionNeurological diseaseParkinson’s disease

Identifiers

PMID38887056
PMCPMC11300401

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.