Evidence map›Paper›PMID 38886975›Full record

ArticlePharmacology research & perspectives2024

Interplay between microbial-derived GABA and host GABA receptor signaling collectively influence the tumorigenic function of GABA in colon cancer.

Jonathan M Keane, Philana Fernandes, Florian Kratz, Grace O'Callaghan, Cormac G M Gahan, Susan A Joyce, Catherine Stanton, Niall P Hyland, Aileen Houston

Abstract read
In one paragraph

Article in Pharmacology research & perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jonathan M KeaneAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID https://orcid.org/0009-0006-3390-9132
Philana FernandesDepartment of Medicine, University College Cork, Cork, Ireland.
Florian KratzAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Grace O'CallaghanDepartment of Medicine, University College Cork, Cork, Ireland.
Cormac G M GahanAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID https://orcid.org/0000-0003-2385-8192
Susan A JoyceAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID https://orcid.org/0000-0003-4771-3123
Catherine StantonAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID https://orcid.org/0000-0002-6724-7011
Niall P HylandAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID https://orcid.org/0000-0003-0060-7390
Aileen HoustonAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID https://orcid.org/0000-0003-1362-5256

Funding

Science Foundation Ireland 12/RC/2273_P2
6 · The paper itself

Abstract

Although classically recognized as a neurotransmitter, gamma aminobutyric acid (GABA) has also been identified in colonic tumors. Moreover, the gut microbiome represents another potential source of GABA. Both GABA

Indexed as

Cell ProliferationColonic Neoplasmsgamma-Aminobutyric AcidGastrointestinal MicrobiomeReceptors, GABA-AReceptors, GABA-BSignal TransductionAnimalsCarcinogenesisCell Line, TumorCyclooxygenase 2DinoprostoneFecesFemaleGlutamate DecarboxylaseHumansCyclooxygenase 2Dinoprostonegamma-Aminobutyric AcidGlutamate DecarboxylaseInterleukin-6Receptors, GABAReceptors, GABA-AReceptors, GABA-Bcolon tumorigenesisgamma‐aminobutyric acidglutamate decarboxylaseinflammationmicrobiomeproliferation

Identifiers

PMID38886975
PMCPMC11182776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.