Evidence map›Paper›PMID 38886580›Full record

ArticleThe EMBO journal2024

Multi-signal regulation of the GSK-3β homolog Rim11 controls meiosis entry in budding yeast.

Johanna Kociemba, Andreas Christ Sølvsten Jørgensen, Nika Tadić, Anthony Harris, Theodora Sideri, Wei Yee Chan, Fairouz Ibrahim, Elçin Ünal, Mark Skehel, Vahid Shahrezaei and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Johanna KociembaThe Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Andreas Christ Sølvsten JørgensenDepartment of Mathematics, Imperial College London, London, SW7 2BX, UK.
Nika TadićDepartment of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, 27695-7612, USA.
Anthony HarrisDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0001-6270-0481
Theodora SideriThe Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Wei Yee ChanThe Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Fairouz IbrahimThe Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Elçin ÜnalDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.
Mark SkehelThe Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Vahid ShahrezaeiDepartment of Mathematics, Imperial College London, London, SW7 2BX, UK. v.shahrezaei@imperial.ac.uk.ORCID http://orcid.org/0000-0002-4013-5458
Orlando Argüello-MirandaDepartment of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, 27695-7612, USA. oargell@ncsu.edu.ORCID http://orcid.org/0000-0002-0579-4650
Folkert Jacobus van WervenThe Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. folkert.vanwerven@crick.ac.uk.ORCID http://orcid.org/0000-0002-6685-2084

Funding

Systems biology of quiescence entryR00GM135487 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI ARGÜELLO-MIRANDA, ORLANDO · 2022 to 2024
$747k
HHS | NIH | National Institute of General Medical Sciences (NIGMS) R00GM135487NIGMS NIH HHS R00 GM135487Wellcome Trust CC2043
6 · The paper itself

Abstract

Starvation in diploid budding yeast cells triggers a cell-fate program culminating in meiosis and spore formation. Transcriptional activation of early meiotic genes (EMGs) hinges on the master regulator Ime1, its DNA-binding partner Ume6, and GSK-3β kinase Rim11. Phosphorylation of Ume6 by Rim11 is required for EMG activation. We report here that Rim11 functions as the central signal integrator for controlling Ume6 phosphorylation and EMG transcription. In nutrient-rich conditions, PKA suppresses Rim11 levels, while TORC1 retains Rim11 in the cytoplasm. Inhibition of PKA and TORC1 induces Rim11 expression and nuclear localization. Remarkably, nuclear Rim11 is required, but not sufficient, for Rim11-dependent Ume6 phosphorylation. In addition, Ime1 is an anchor protein enabling Ume6 phosphorylation by Rim11. Subsequently, Ume6-Ime1 coactivator complexes form and induce EMG transcription. Our results demonstrate how various signaling inputs (PKA/TORC1/Ime1) converge through Rim11 to regulate EMG expression and meiosis initiation. We posit that the signaling-regulatory network elucidated here generates robustness in cell-fate control.

Indexed as

MeiosisSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal TransductionCyclic AMP-Dependent Protein KinasesGene Expression Regulation, FungalGlycogen Synthase Kinase 3 betaIntracellular Signaling Peptides and ProteinsNuclear ProteinsPhosphorylationProtein Serine-Threonine KinasesRepressor ProteinsTranscription FactorsCyclic AMP-Dependent Protein KinasesGlycogen Synthase Kinase 3 betaIME1 protein, S cerevisiaeIntracellular Signaling Peptides and ProteinsNuclear ProteinsProtein Serine-Threonine KinasesRepressor ProteinsRIM11 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsUME6 protein, S cerevisiaeGSK-3βMeiosisRim11Ume6Yeast

Identifiers

PMID38886580
PMCPMC11294583

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.