Evidence map›Paper›PMID 38886569›Full record

ArticleOncogene2024

Role of gut microbiota in the pathogenesis of castration-resistant prostate cancer: a comprehensive study using sequencing and animal models.

Guowen Lin, Feng Zhang, Xiaoling Weng, Zhe Hong, Dingwei Ye, Gangmin Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guowen Lin *Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. linguowen@fudan.edu.cn.ORCID 0009-0005-6898-0441
Feng Zhang *Department Of Urology, Shanghai Eighth People's Hospital, Shanghai, 200235, China.
Xiaoling Weng *State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Zhe HongDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. hz_urology@shca.org.cn.
Dingwei YeDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. dwyeli@163.com.ORCID 0000-0003-4974-3780
Gangmin WangDepartment of Urology, Huashan Hospital, Fudan University, Shanghai, 200040, China. 15921116056@163.com.ORCID 0009-0009-2209-7994

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRPC remains a significant challenge in prostate cancer research. We aimed to elucidate the role of gut microbiota and its specific mechanisms in CRPC using a multidisciplinary approach. We analyzed 16S rRNA sequencing data from mouse fecal samples, revealing substantial differences in gut microbiota composition between CRPC and castration-sensitive prostate cancer mice, particularly in Firmicutes and Bacteroidetes. Functional analysis suggested different bacteria may influence CRPC via the α-linolenic acid metabolism pathway. In vivo, experiments utilizing mouse models and fecal microbiota transplantation (FMT) demonstrated that FMT from healthy control mice could decelerate tumor growth in CRPC mice, reduce TNF-α levels, and inhibit the activation of the TLR4/MyD88/NF-κB signaling pathway. Transcriptome sequencing identified crucial genes and pathways, with rescue experiments confirming the gut microbiota's role in modulating CRPC progression through the TLR4/MyD88/NF-κB pathway. The activation of this pathway by TNF-α has been corroborated by in vitro cell experiments, indicating its role in promoting prostate cancer cell proliferation, migration, and invasion while inhibiting apoptosis. Gut microbiota dysbiosis may promote CRPC development through TNF-α activation of the TLR4/MyD88/NF-κB signaling pathway, potentially linked to α-linolenic acid metabolism.

Indexed as

Gastrointestinal MicrobiomeMyeloid Differentiation Factor 88Prostatic Neoplasms, Castration-ResistantToll-Like Receptor 4AnimalsCell Line, TumorCell ProliferationDisease Models, AnimalDysbiosisFecal Microbiota TransplantationHumansMaleMiceNF-kappa BRNA, Ribosomal, 16SSignal TransductionMyeloid Differentiation Factor 88NF-kappa BRNA, Ribosomal, 16SToll-Like Receptor 4Tumor Necrosis Factor-alpha

Identifiers

PMID38886569

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.