Evidence map›Paper›PMID 38886507›Full record

ArticlePediatric research2025

Mechanical power made simple: validating a simplified calculation of mechanical power in preterm lungs.

Jack Pearson-Lemme, Ikhwan Halibullah, Tobias Becher, Hamish D Tingay, Ellen Douglas, Monique Fatmous, Kelly R Kenna, Prue M Pereira-Fantini, David G Tingay, Arun Sett

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jack Pearson-LemmeDepartment of Paediatrics, University of Melbourne, Melbourne, VIC, Australia.
Ikhwan HalibullahNewborn Services, Joan Kirner Women's and Children's, Sunshine Hospital, Western Health, Melbourne, VIC, Australia.
Tobias BecherDepartment of Anaesthesiology and Intensive Care Medicine, University Medical Centre Schleswig-Holstein, Schleswig-Holstein, Germany.
Hamish D TingayNeonatal Research, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Ellen DouglasNeonatal Research, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Monique FatmousNeonatal Research, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Kelly R KennaNeonatal Research, Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Prue M Pereira-FantiniDepartment of Paediatrics, University of Melbourne, Melbourne, VIC, Australia.
David G TingayDepartment of Paediatrics, University of Melbourne, Melbourne, VIC, Australia.
Arun SettNewborn Services, Joan Kirner Women's and Children's, Sunshine Hospital, Western Health, Melbourne, VIC, Australia. arun.sett@mcri.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe incidence of chronic lung disease is increasing, suggesting a need to explore novel ways to understand ventilator induced lung injury (VILI) in preterm infants. Mechanical power (MP) is a unifying measure of energy transferred to the respiratory system and a proposed determinant of VILI. The gold-standard method for calculating MP (geometric method) is not feasible in the clinical setting. This has prompted the derivation of simplified equations for calculating MP.

objectiveTo validate the agreement between a simplified calculation of MP (MP

methodsMP

resultsA strong linear relationship (adjusted R

conclusionsIn a controlled setting, there was excellent agreement between MP IMPACT STATEMENT: Mechanical power (MP) unifies the individual components of ventilator induced lung injury (VILI) and provides an estimate of total energy transferred to the respiratory system during mechanical ventilation. As gold-standard calculations of mechanical power at the bedside are not feasible, alternative simplified equations have been proposed. In this study, MP calculated using a simplified equation had excellent agreement with true MP in mechanically ventilated preterm lambs. These results lay foundations to explore the role of MP in neonatal VILI and determine its relationship with short and long term respiratory outcomes.

Indexed as

LungRespiration, ArtificialVentilator-Induced Lung InjuryAnimalsAnimals, NewbornHumansInfant, NewbornInfant, PrematureReproducibility of ResultsSheep

Identifiers

PMID38886507
PMCPMC11798860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.