Evidence map›Paper›PMID 38886466›Full record

ArticleScientific reports2024

The Nurr1 ligand indole acetic acid hydrazide loaded onto ZnFe2O4 nanoparticles suppresses proinflammatory gene expressions in SimA9 microglial cells.

Raneen Qasim, Tuqa Abu Thiab, Tareq Alhindi, Afnan Al-Hunaiti, Amer Imraish

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Raneen QasimDepartment of Biological Sciences, School of Science, The University of Jordan, Queen Rania Al-Abdullah Street, Amman, 11942, Jordan.
Tuqa Abu ThiabDepartment of Biological Sciences, School of Science, The University of Jordan, Queen Rania Al-Abdullah Street, Amman, 11942, Jordan.
Tareq AlhindiDepartment of Biological Sciences, School of Science, The University of Jordan, Queen Rania Al-Abdullah Street, Amman, 11942, Jordan.
Afnan Al-HunaitiDepartment of Chemistry, School of Science, The University of Jordan, Queen Rania Al-Abdullah Street, Amman, 11942, Jordan.
Amer ImraishDepartment of Biological Sciences, School of Science, The University of Jordan, Queen Rania Al-Abdullah Street, Amman, 11942, Jordan. a.imraish@ju.edu.jo.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nuclear receptor-related factor 1 (Nurr1), an orphan nuclear receptor in microglia, has been recognized as a major player in attenuating the transcription of the pro-inflammatory genes to maintain CNS homeostasis. In this study, we investigate Nurr1 trans-repression activity by targeting this receptor with one of the indole derivatives 3-Indole acetic acid hydrazide (IAAH) loaded onto zinc iron oxide (ZnFe

Indexed as

MicrogliaNanoparticlesNuclear Receptor Subfamily 4, Group A, Member 2AnimalsAnti-Inflammatory AgentsCell LineCytokinesFerric CompoundsGene Expression RegulationIndoleacetic AcidsIndolesInflammationLigandsLipopolysaccharidesMiceAnti-Inflammatory AgentsCytokinesFerric Compoundsindoleacetic acidIndoleacetic AcidsIndolesLigandsLipopolysaccharidesNr4a2 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 23-Indole acetic acid hydrazideAnti-inflammatoryMicrogliaNanoparticlesNurr1

Identifiers

PMID38886466
PMCPMC11183088

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.