Evidence map›Paper›PMID 38886452›Full record

ArticleScientific reports2024

Advanced optical assessment and modeling of extrusion bioprinting.

Zan Lamberger, Dirk W Schubert, Margitta Buechner, Nathaly Chicaiza Cabezas, Stefan Schrüfer, Nicoletta Murenu, Natascha Schaefer, Gregor Lang

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
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  3. Article
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  5. Article
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  8. Review
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  10. Review
  11. Article
  12. Droplet-based bioprinting.Nature reviews. Methods primers · 2025
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zan Lamberger *Department for Functional Materials in Medicine and Dentistry, University Hospital of Würzburg, 97070, Würzburg, Germany.
Dirk W Schubert *Department of Materials Science and Engineering, University of Erlangen-Nuremberg, 91058, Erlangen, Germany.
Margitta BuechnerDepartment of Materials Science and Engineering, University of Erlangen-Nuremberg, 91058, Erlangen, Germany.
Nathaly Chicaiza CabezasDepartment for Functional Materials in Medicine and Dentistry, University Hospital of Würzburg, 97070, Würzburg, Germany.
Stefan SchrüferDepartment of Materials Science and Engineering, University of Erlangen-Nuremberg, 91058, Erlangen, Germany.
Nicoletta MurenuInstitute for Clinical Neurobiology, University Hospital of Würzburg, 97078, Würzburg, Germany.
Natascha SchaeferInstitute for Clinical Neurobiology, University Hospital of Würzburg, 97078, Würzburg, Germany.
Gregor LangDepartment for Functional Materials in Medicine and Dentistry, University Hospital of Würzburg, 97070, Würzburg, Germany. gregor.lang@uni-wuerzburg.de.ORCID 0000-0001-9819-8630

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 326998133
6 · The paper itself

Abstract

In the context of tissue engineering, biofabrication techniques are employed to process cells in hydrogel-based matrices, known as bioinks, into complex 3D structures. The aim is the production of functional tissue models or even entire organs. The regenerative production of biological tissues adheres to a multitude of criteria that ultimately determine the maturation of a functional tissue. These criteria are of biological nature, such as the biomimetic spatial positioning of different cell types within a physiologically and mechanically suitable matrix, which enables tissue maturation. Furthermore, the processing, a combination of technical procedures and biological materials, has proven highly challenging since cells are sensitive to stress, for example from shear and tensile forces, which may affect their vitality. On the other hand, high resolutions are pursued to create optimal conditions for subsequent tissue maturation. From an analytical perspective, it is prudent to first investigate the printing behavior of bioinks before undertaking complex biological tests. According to our findings, conventional shear rheological tests are insufficient to fully characterize the printing behavior of a bioink. For this reason, we have developed optical methods that, complementarily to the already developed tests, allow for quantification of printing quality and further viscoelastic modeling of bioinks.

Indexed as

BioprintingHydrogelsPrinting, Three-DimensionalTissue EngineeringHumansRheologyTissue ScaffoldsViscosityHydrogelsBiofabricationBioinkBioprintingExtrusionModelingRheology

Identifiers

PMID38886452
PMCPMC11183084

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.