ArticleNature communications2024
Organic fertilization co-selects genetically linked antibiotic and metal(loid) resistance genes in global soil microbiome.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Systematic citywide analysis reveals ecological connectivity of antimicrobial resistance genes across urban water systems.Nature communications · 2026Article
- Dominant Role of Habitat Transformation in Driving the Divergence of Health-Risk Related Microbial Functional Genes in Karst Mountain Parks: A Metagenomic Study.Ecology and evolution · 2026Article
- Impacts of pollution on the soil microbiome.Nature reviews. Microbiology · 2026Review
- Environmental effectiveness of the National Action Plan to Contain Antimicrobial Resistance: evidence from Chinese soil.National science review · 2026Article
- Nitrate-reducing bacteria bridge nitrogen cycling and antibiotic resistance in river ecosystems.Nature communications · 2026Article
- An integrated global resource of wetland microbiomes linking environmental metadata, community profiles, and genome-resolved metabolic traits.Scientific data · 2026Article
- Nutrition cycling microbiomes drive the succession of antibiotic resistome in long-term manured soils.Journal of advanced research · 2026Article
- Dissemination of antimicrobial resistance in Klebsiella spp. from urban aquatic environments: a multi-country genomic perspective.Journal of advanced research · 2026Article
- Effects of different cultivation methods on microbial community structure of lettuce based on metagenomic analysis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Long-Term Application of Fermented Fertilizer Attenuates the Accumulation of Antibiotic Resistance Genes in Aquaculture Sediment.Microorganisms · 2026Article
- Mapping the Convergence of Frontier Technologies for Major Environmental Challenges: A Chemical and Molecular Perspective on the Use of AI for Climate Action and Antimicrobial Resistance.Molecules (Basel, Switzerland) · 2026Review
- Root Exudates Are Linked to Antibiotic Resistance Gene Variation by Modulating Rhizosphere Microbial Community Assembly Under Swine Wastewater Irrigation.Antibiotics (Basel, Switzerland) · 2026Article
- Article
- Plant spatial compartmentalization buffers bacteriome structure and function under antibiotic stress.Scientific reports · 2026Article
- Transmission and Evolution of Antibiotic Resistance Genes and Antibiotic-Resistant Bacteria in Animals, Food, Humans and the Environment.Microorganisms · 2026Review
- Spatially resolved denitrification coupled with methane and arsenite oxidation at the millimeter-scale straw-soil interface.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Persistent antimicrobial resistance during soil remediation driven by residual heavy metal co-selection.The ISME journal · 2026Article
- High molecular weight dissolved organic matter drives soil resistome proliferation by enhancing microbial competition and viral carbon metabolism.The ISME journal · 2026Article
- Genome-resolved metagenomics reveals co-selection of antibiotic and metal resistance in chronically polluted industrial soils.Frontiers in microbiology · 2026Article
- Draft genome of a manganese-oxidizing bacteriumMicrobiology resource announcements · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Antibiotic resistance genes (ARGs) and metal(loid) resistance genes (MRGs) coexist in organic fertilized agroecosystems based on their correlations in abundance, yet evidence for the genetic linkage of ARG-MRGs co-selected by organic fertilization remains elusive. Here, an analysis of 511 global agricultural soil metagenomes reveals that organic fertilization correlates with a threefold increase in the number of diverse types of ARG-MRG-carrying contigs (AMCCs) in the microbiome (63 types) compared to non-organic fertilized soils (22 types). Metatranscriptomic data indicates increased expression of AMCCs under higher arsenic stress, with co-regulation of the ARG-MRG pairs. Organic fertilization heightens the coexistence of ARG-MRG in genomic elements through impacting soil properties and ARG and MRG abundances. Accordingly, a comprehensive global map was constructed to delineate the distribution of coexistent ARG-MRGs with virulence factors and mobile genes in metagenome-assembled genomes from agricultural lands. The map unveils a heightened relative abundance and potential pathogenicity risks (range of 4-6) for the spread of coexistent ARG-MRGs in Central North America, Eastern Europe, Western Asia, and Northeast China compared to other regions, which acquire a risk range of 1-3. Our findings highlight that organic fertilization co-selects genetically linked ARGs and MRGs in the global soil microbiome, and underscore the need to mitigate the spread of these co-resistant genes to safeguard public health.
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