Evidence map›Paper›PMID 38886409›Full record

ArticleNature communications2024

Environmental and genetic regulation of Streptococcus pneumoniae galactose catabolic pathways.

Banaz O Kareem, Ozcan Gazioglu, Karina Mueller Brown, Medhanie Habtom, David G Glanville, Marco R Oggioni, Peter W Andrew, Andrew T Ulijasz, N Luisa Hiller, Hasan Yesilkaya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Increased vaginalmSystems · 2025
    Article
  4. The Influence of Carbohydrates on the Virulence Potential ofInternational journal of microbiology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Banaz O Kareem *Department of Respiratory Sciences, University of Leicester, Leicester, UK.
Ozcan Gazioglu *Department of Respiratory Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0002-2102-6918
Karina Mueller BrownDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-5310-9876
Medhanie HabtomDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.
David G GlanvilleDepartment of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, USA.ORCID http://orcid.org/0000-0002-8487-5941
Marco R OggioniDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0003-4117-793X
Peter W AndrewDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.
Andrew T UlijaszDepartment of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, USA.ORCID http://orcid.org/0000-0003-0739-1297
N Luisa HillerDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-6572-1368
Hasan YesilkayaDepartment of Respiratory Sciences, University of Leicester, Leicester, UK. hy3@le.ac.uk.ORCID http://orcid.org/0000-0003-3617-1437

Funding

A Regulatory Cascade that Controls Pneumococcal Capsule BiosynthesisR01AI135060 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI ULIJASZ, ANDREW T · 2019 to 2023
$2.3M
Deciphering the Role of Rgg in the Pneumococcal Signaling, Colonization and Virulence PortfolioR01AI139077 · NIAID · CARNEGIE-MELLON UNIVERSITY · PI HILLER, NATALIA LUISA · 2019 to 2023
$1.9M
A novel family of conserved glyoxal toxicity response proteins.R01GM141230 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ULIJASZ, ANDREW T · 2022 to 2025
$1.7M
NIAID NIH HHS R01 AI135060NIAID NIH HHS R01 AI139077NIGMS NIH HHS R01 GM141230U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01 AI135060-01A1U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01 AI139077-01A1
6 · The paper itself

Abstract

Efficient utilization of nutrients is crucial for microbial survival and virulence. The same nutrient may be utilized by multiple catabolic pathways, indicating that the physical and chemical environments for induction as well as their functional roles may differ. Here, we study the tagatose and Leloir pathways for galactose catabolism of the human pathogen Streptococcus pneumoniae. We show that galactose utilization potentiates pneumococcal virulence, the induction of galactose catabolic pathways is influenced differentially by the concentration of galactose and temperature, and sialic acid downregulates galactose catabolism. Furthermore, the genetic regulation and in vivo induction of each pathway differ, and both galactose catabolic pathways can be turned off with a galactose analogue in a substrate-specific manner, indicating that galactose catabolic pathways can be potential drug targets.

Indexed as

GalactoseGene Expression Regulation, BacterialStreptococcus pneumoniaeAnimalsBacterial ProteinsFemaleHexosesHumansMetabolic Networks and PathwaysMiceN-Acetylneuraminic AcidPneumococcal InfectionsTemperatureVirulenceBacterial ProteinsGalactoseHexosesN-Acetylneuraminic Acidtagatose

Identifiers

PMID38886409
PMCPMC11183247

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.