Evidence map›Paper›PMID 38886398›Full record

ArticleScientific reports2024

Comparison of juvenile and adult myasthenia gravis in a French cohort with focus on thymic histology.

Frédérique Truffault, Ludivine Auger, Nadine Dragin, Jean-Thomas Vilquin, Elie Fadel, Vincent Thomas de Montpreville, Audrey Mansuet-Lupo, Jean-François Regnard, Marco Alifano, Tarek Sharshar and 6 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Frédérique TruffaultCenter of Research in Myology, Institute of Myology, INSERM, Sorbonne University, 105, Boulevard de l'Hôpital, 75013, Paris, France.
Ludivine AugerCenter of Research in Myology, Institute of Myology, INSERM, Sorbonne University, 105, Boulevard de l'Hôpital, 75013, Paris, France.
Nadine DraginCenter of Research in Myology, Institute of Myology, INSERM, Sorbonne University, 105, Boulevard de l'Hôpital, 75013, Paris, France.
Jean-Thomas VilquinCenter of Research in Myology, Institute of Myology, INSERM, Sorbonne University, 105, Boulevard de l'Hôpital, 75013, Paris, France.
Elie FadelMarie Lannelongue Hospital, Paris Saclay University, Le Plessis-Robinson, France.
Vincent Thomas de MontprevilleMarie Lannelongue Hospital, Paris Saclay University, Le Plessis-Robinson, France.
Audrey Mansuet-LupoDepartment of Pathology, Cochin University Hospital Group, AP-HP, Paris-Descartes University, Paris, France.
Jean-François RegnardDepartment of Pathology, Cochin University Hospital Group, AP-HP, Paris-Descartes University, Paris, France.
Marco AlifanoDepartment of Pathology, Cochin University Hospital Group, AP-HP, Paris-Descartes University, Paris, France.
Tarek SharsharAnesthesia and Intensive Care Department, GHU Paris Psychiatrie et Neurosciences, Pole Neuro, Sainte‑Anne Hospital, Paris, Institute of Psychiatry and Neurosciences of Paris, INSERM U1266, Université Paris Cité, Paris, France.
Anthony BehinAP-HP, Referral Center for Neuromuscular Disorders, Institute of Myology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France.
Bruno EymardAP-HP, Referral Center for Neuromuscular Disorders, Institute of Myology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France.
Francis BolgertNeuro-Intensive Care Unit, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, Paris, France.
Sophie DemeretNeuro-Intensive Care Unit, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, Paris, France.
Sonia Berrih-AkninCenter of Research in Myology, Institute of Myology, INSERM, Sorbonne University, 105, Boulevard de l'Hôpital, 75013, Paris, France.
Rozen Le PanseCenter of Research in Myology, Institute of Myology, INSERM, Sorbonne University, 105, Boulevard de l'Hôpital, 75013, Paris, France. rozen.lepanse@upmc.fr.

Funding

European Commission MYASTAID/LSHM-CT-2006-037833FP7 Health FIGHT-MG/HEALTH-2009-242-210
6 · The paper itself

Abstract

Myasthenia gravis (MG) is an autoimmune disease characterized by muscle fatigability due to acetylcholine receptor (AChR) autoantibodies. To better characterize juvenile MG (JMG), we analyzed 85 pre- and 132 post-pubescent JMG (with a cutoff age of 13) compared to 721 adult MG patients under 40 years old using a French database. Clinical data, anti-AChR antibody titers, thymectomy, and thymic histology were analyzed. The proportion of females was higher in each subgroup. No significant difference in the anti-AChR titers was observed. Interestingly, the proportion of AChR

Indexed as

AutoantibodiesMyasthenia GravisReceptors, CholinergicThymectomyThymus GlandAdolescentAdultChildCohort StudiesFemaleFranceGerminal CenterHumansMaleYoung AdultAutoantibodiesReceptors, CholinergicAgeAutoimmunityFollicular hyperplasiaPubertyThymectomyThymus

Identifiers

PMID38886398
PMCPMC11183198

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.