Evidence map›Paper›PMID 38886383›Full record

ArticleCell death & disease2024

The Mohawk homeobox gene represents a marker and osteo-inhibitory factor in calvarial suture osteoprogenitor cells.

Yiyun Wang, Qizhi Qin, Ziyi Wang, Stefano Negri, Takashi Sono, Robert J Tower, Zhao Li, Xin Xing, Mary Archer, Neelima Thottappillil and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Bridging skeletal stem cell diversity and human skeletal modeling.Journal of bone and mineral metabolism · 2026
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yiyun Wang *Department of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.ORCID 0000-0003-0775-4377
Qizhi Qin *Department of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.ORCID 0000-0001-5437-0208
Ziyi Wang *Department of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Stefano NegriDepartment of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Takashi SonoDepartment of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Robert J TowerDepartment of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Zhao LiDepartment of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Xin XingDepartment of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Mary ArcherDepartment of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Neelima ThottappillilDepartment of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Manyu ZhuDepartment of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Allister SuarezDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Deok-Ho KimDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Tyler HarveyDepartment of Embryology, Carnegie Institution of Washington, Johns Hopkins University, Baltimore, MD, 21218, USA.
Chen-Ming FanDepartment of Embryology, Carnegie Institution of Washington, Johns Hopkins University, Baltimore, MD, 21218, USA.
Aaron W JamesDepartment of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA. awjames@jhmi.edu.ORCID 0000-0002-2002-622X

Funding

Neuronal Regulation of Skeletal Development and RepairR01DE031028 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI CLEMENS, THOMAS L, JAMES, AARON W · 2021 to 2025
$2.3M
Direct and indirect contributions of perivascular stem cells to bone healingR01AR070773 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI JAMES, AARON W · 2017 to 2021
$1.4M
Defining the human adventitial stem cell nicheR21AR078919 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI JAMES, AARON W, PEAULT, BRUNO M · 2022 to 2023
$404k
NIAMS NIH HHS R01 AR070773NIAMS NIH HHS R21 AR078919NIDCR NIH HHS R01 DE031028U.S. Department of Defense (United States Department of Defense) W81XWH-18-1-0336
6 · The paper itself

Abstract

The regeneration of the mammalian skeleton's craniofacial bones necessitates the action of intrinsic and extrinsic inductive factors from multiple cell types, which function hierarchically and temporally to control the differentiation of osteogenic progenitors. Single-cell transcriptomics of developing mouse calvarial suture recently identified a suture mesenchymal progenitor population with previously unappreciated tendon- or ligament-associated gene expression profile. Here, we developed a Mohawk homeobox (Mkx

Indexed as

Cell DifferentiationHomeodomain ProteinsOsteogenesisSkullAnimalsBiomarkersCranial SuturesMiceOsteoblastsStem CellsBiomarkersHomeodomain Proteinsmohawk protein, mouse

Identifiers

PMID38886383
PMCPMC11183145

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.