ArticleNature communications2024
Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2.
Abstract read
In one paragraph
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Mechanistic target of rapamycin complex-1 plays a role in inhibiting kidney KAmerican journal of physiology. Renal physiology · 2026Article
- Potassium and the kidney.Nature reviews. Nephrology · 2026Review
- How Does Dietary Potassium Influence BP?Journal of the American Society of Nephrology : JASN · 2026Review
- Tertiary Lymphoid Structure-Like Lymphocyte Aggregate Generation in Human and Mouse Hypokalaemic Nephropathy: Research Letter.Canadian journal of kidney health and disease · 2026Article
- KiScience · 2025Article
- KCC3 is not required for the distal convoluted tubule response to reduced dietary potassium intake.American journal of physiology. Renal physiology · 2025Article
- The physiological characteristics of inward rectifying potassium channel Kir4.2 and its research progress in human diseases.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Yahua ZhangDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Fabian BockDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Mohammed FerdausDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Juan Pablo ArroyoDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-5992-5011
Kristie L RoseDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.
Purvi PatelMass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Jerod S DentonDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Eric DelpireDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Alan M WeinsteinDepartment of Physiology and Biophysics, Weil Medical College, New York, NY, USA.
Ming-Zhi ZhangDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-0980-2419
Raymond C HarrisDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Andrew S TerkerDivision of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Andrew.s.terker@vumc.org.ORCID http://orcid.org/0000-0003-1498-9043
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3MOverall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3MThe role of the innate immune cell cyclooxygenase/prostaglandin system in blood pressureregulationR01DK062794 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2003 to 2026
$9.4MThe Role of renal macrophages in recovery from renal injuryR01DK095785 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2013 to 2026
$6.7MVanderbilt O'Brien Kidney Center - Core D - Clinical and Translational CoreP30DK114809 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DE CAESTECKER, MARK P. · 2017 to 2021
$5.9MVANDERBILT NEPHROLOGY TRAINING PROGRAMT32DK007569 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRIS, RAYMOND C., IKIZLER, TALAT ALP · 1988 to 2024
$5.8MTHEORY OF SOLUTE AND WATER TRANSPORT ACROSS EPITHELIAR01DK029857 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI WEINSTEIN, ALAN M · 1986 to 2022
$3.8MInnovative therapeutic approaches to treat chronic kidney diseaseDP5OD033412 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TERKER, ANDREW S. · 2022 to 2025
$2.2MUnderstanding the physiology and pathophysiology of kidney-derived vasopressinK08DK135931 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Juan Pablo Arroyo Ornelas · 2023 to 2026
$696kRac1 and the actin cytoskeleton in renal tubular repairK08DK134879 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Fabian Maximilian Bock · 2023 to 2026
$636kNCI NIH HHS P30 CA068485NICHD NIH HHS P50 HD103537NIDDK NIH HHS K08 DK134879NIDDK NIH HHS K08 DK135931NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK114809NIDDK NIH HHS R01 DK029857NIDDK NIH HHS R01 DK062794NIDDK NIH HHS R01 DK095785NIDDK NIH HHS T32 DK007569NIH HHS DP5 OD033412U.S. Department of Health & Human Services | National Institutes of Health (NIH) DP5OD033412
Abstract
The renal epithelium is sensitive to changes in blood potassium (K
Indexed as
Kidney Tubules, ProximalMechanistic Target of Rapamycin Complex 2Mice, KnockoutPotassiumPotassium Channels, Inwardly RectifyingProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesAnimalsChloridesKcnj10 ChannelMaleMiceMice, Inbred C57BLPhosphorylationChloridesKcnj10 ChannelMechanistic Target of Rapamycin Complex 2mTOR protein, mousePotassiumPotassium Channels, Inwardly RectifyingProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinases
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.