Evidence map›Paper›PMID 38886276›Full record

ArticleInsights into imaging2024

Association between higher intermuscular adipose tissue and decreased renal function in patients with systemic lupus erythematosus mediated by insulin resistance.

Bowen Wang, Liping Zuo, Jinlei Fan, Yu Ji, Lei Xu, Min Xu, Yueming An, Yuting Zhang, Guanming Ji, Deixin Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Insights into imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Intermuscular Adipose Tissue in CKD: A Window into Muscle Quality and Health?Clinical journal of the American Society of Nephrology : CJASN · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bowen Wang *Department of Radiology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
Liping Zuo *Department of Radiology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
Jinlei FanDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
Yu JiDepartment of Radiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, China.
Lei XuMedical Imaging Department, Shengli Oilfield Central Hospital, Dongying, Shandong, 257100, China.
Min XuDepartment of Radiology, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, Shandong, 264200, China.
Yueming AnDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
Yuting ZhangDepartment of Arrhythmia, Weifang People's Hospital, Weifang, Shandong, 261000, China.
Guanming JiMedical Imaging Department, Shengli Oilfield Central Hospital, Dongying, Shandong, 257100, China.
Deixin YuDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China. yudexin0330@sina.com.ORCID http://orcid.org/0000-0002-3430-4817

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo quantify the relationship between abdominal computed tomography (CT)-based body composition parameters and renal function in systemic lupus erythematosus (SLE) patients and evaluate the potential effect of insulin resistance on this relationship.

methodsSLE patients from institutions A and B between January 2017 and August 2023 were enrolled. Areas and attenuation values of subcutaneous adipose tissue, visceral adipose tissue, intermuscular adipose tissue (IMAT), and skeletal muscle index on CT images were measured at the L3 vertebral level. Logistic regression analysis was used to identify risk factors associated with decreased renal function. Linear regression models were used to describe the relationships between body composition parameters and estimated glomerular filtration rate (eGFR). Finally, we used a single-point insulin sensitivity estimator to indirectly reflect the degree of insulin resistance and assess its mediating effect on the association between IMAT area and decreased renal function.

resultsThree-hundred thirty-nine SLE patients from institution A (internal dataset) and 114 SLE patients from institution B (external validation dataset) were included. Multivariate logistic regression revealed that IMAT area (odds ratio (OR)

conclusionHigh IMAT area was associated with decreased renal function in SLE patients and insulin resistance mediated this relationship. CRITICAL RELEVANCE STATEMENT: High intermuscular adipose tissue area is associated with decreased renal function in systemic lupus erythematosus patients mediated by insulin resistance and is correlated with chronicity index in lupus nephritis patients. KEY POINTS: High intramuscular adipose tissue (IMAT) area was associated with decreased renal function in systemic lupus erythematosus (SLE) patients. Insulin resistance mediated the association between IMAT area and eGFR. IMAT area was associated with chronicity index in lupus nephritis patients.

Indexed as

Body compositionGlomerular filtration rateInsulin resistanceSystemic lupus erythematosusTomography (X-ray computed)

Identifiers

PMID38886276
PMCPMC11182995

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.