ArticleSurgical endoscopy2024
Global 30-day morbidity and mortality of surgery for perforated peptic ulcer: GRACE study.
Article in Surgical endoscopy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Diagnostic utility of a CT upper gastrointestinal protocol for the detection of gastroduodenal leaks.Abdominal radiology (New York) · 2026Article
- Outcomes and Predictors of Mortality in Perforated Versus Non-Perforated Peptic Ulcer Disease: A U.S. Nationwide Propensity-Matched Analysis, 2016-2021.Journal of clinical medicine · 2026Article
- Article
- Article
- Evidence-based, cost-effective management of perforated peptic ulcer disease: An algorithm of the Journal of Trauma and Acute Care Surgery Emergency General Surgery Algorithms Working Group.The journal of trauma and acute care surgery · 2026Article
- Perforated peptic ulcer disease in a resource-limited setting: a retrospective analysis of a South African cohort.BMC gastroenterology · 2026Article
- Review
- Postoperative enteral nutrition timing and risk variation in elderly patients with perforated peptic ulcer.Frontiers in nutrition · 2026Article
- Risk factor analysis and surgical outcomes in emergency gastrectomy for gastric perforation: a single-center retrospective cohort study.Annals of surgical treatment and research · 2025Article
- A Case of a Perforated Duodenal Ulcer in the Context of Acute Tubular Necrosis and Urosepsis.Cureus · 2025Article
- Article
- Laparoscopic surgery in acute perforated gastroduodenal ulcers: an underutilized technique despite favorable short-term outcomes.Surgical endoscopy · 2025Article
- Predictive Value of the Red Cell Distribution Width-To-Albumin Ratio for Clinical Outcomes in Patients With Peptic Ulcer Perforation.World journal of surgery · 2025Article
- Risk factors and predictive model construction for severe complications following repair of perforated peptic ulcer.Frontiers in surgery · 2025Article
- The Role of Microbiome in Cardiovascular Health: Insights for Primary Care Interventions.Cureus · 2024Review
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Authors and funding
100 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is little international data on morbidity and mortality of surgery for perforated peptic ulcer (PPU). This study aimed to understand the global 30-day morbidity and mortality of patients undergoing surgery for PPU and to identify variables associated with these.
methodWe performed an international study of adults (≥ 18 years) who underwent surgery for PPU from 1st January 2022 to 30th June 2022. Patients who were treated conservatively or had an underlying gastric cancer were excluded. Patients were divided into subgroups according to age (≤ 50 and > 50 years) and time from onset of symptoms to hospital presentation (≤ 24 and > 24 h). Univariate and Multivariate analyses were carried out to identify factors associated with higher 30-day morbidity and mortality.
results1874 patients from 159 centres across 52 countries were included. 78.3% (n = 1467) of the patients were males and the median (IQR) age was 49 years (25). Thirty-day morbidity and mortality were 48.5% (n = 910) and 9.3% (n = 174) respectively. Median (IQR) hospital stay was 7 (5) days. Open surgery was performed in 80% (n = 1505) of the cohort. Age > 50 years [(OR = 1.7, 95% CI 1.4-2), (OR = 4.7, 95% CI 3.1-7.6)], female gender [(OR = 1.8, 95% CI 1.4-2.3), (OR = 1.9, 95% CI 1.3-2.9)], shock on admission [(OR = 2.1, 95% CI 1.7-2.7), (OR = 4.8, 95% CI 3.2-7.1)], and acute kidney injury [(OR = 2.5, 95% CI 1.9-3.2), (OR = 3.9), 95% CI 2.7-5.6)] were associated with both 30-day morbidity and mortality. Delayed presentation was associated with 30-day morbidity [OR = 1.3, 95% CI 1.1-1.6], but not mortality.
conclusionsThis study showed that surgery for PPU was associated with high 30-day morbidity and mortality rate. Age, female gender, and signs of shock at presentation were associated with both 30-day morbidity and mortality.
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