Evidence map›Paper›PMID 38886192›Full record

ArticleAnnals of hematology2024

Clinicopathological analysis of immunohistochemical CD47 and signal-regulatory protein-α expression in Extranodal Natural killer/T-cell lymphoma.

Zaixiang Tan, Qing Zhang, Ying Wang, Yubo Wang, Shuo Zhang, Xing Xing, Hui Liu, Ziyuan Shen, Wei Sang

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Article in Annals of hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Zaixiang Tan *Research Center of Health Policy and Health Management, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
Qing Zhang *Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.
Ying WangResearch Center of Health Policy and Health Management, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
Yubo WangDepartment of Pathology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
Shuo ZhangDepartment of Hematology, Linyi People's Hospital, Linyi, Shandong, 276002, China.
Xing XingDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China.
Hui LiuDepartment of Pathology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
Ziyuan ShenDepartment of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.
Wei SangDepartment of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China. xyfylbl515@xzhmu.edu.cn.ORCID http://orcid.org/0000-0002-1170-7074

Funding

Jiangsu Key Research and Development Project of Social Development BE2019638Natural Science Foundation of Jiangsu Province BK20171181Young Medical Talents of Jiangsu Science and Education Health Project QNRC2016791
6 · The paper itself

Abstract

backgroundThe interaction between CD47 and signal-regulatory protein-alpha (SIRPα) inhibits phagocytosis, and their clinicopathological characteristics have been evaluated in various diseases. However, the significance of CD47 and SIRPα expression, as well as the combined effect, in Extranodal Natural killer/T-cell Lymphoma (ENKTL) remains uncertain.

methodsIn total, 76 newly diagnosed ENKTL patients (mean age 49.9 years, 73.7% male) were included in this study. CD47 and SIRPα expression were examined by immunohistochemistry. Survival analyses were conducted through Kaplan-Meier curves and the Cox regression model.

resultsSeventy-one (93.4%) cases were categorized as the CD47 positive group and 59 (77.6%) cases were categorized as the SIRPα positive group. CD47-negative cases had more advanced-stage illness (P = 0.001), while SIRPα-positive cases showed significantly lower levels of high-density lipoprotein (P < 0.001). In univariable analysis, CD47, SIRPα expression, and their combination were significantly associated with prognosis (P < 0.05). In multivariable analysis, only positive SIRPα expression remained significantly associated with superior overall survival (Hazard ratio [HR] 0.446; 95% confidence interval [CI] 0.207-0.963; P = 0.004). Furthermore, SIRPα expression could re-stratify the survival of patients in ECOG (< 2), advanced CA stage, PINK (HR), CD38-positive, PD1-positive, and CD30-positive groups.

conclusionsSIRPα status was a potential independent prognostic factor for ENKTL. The prognostic significance of CD47 expression and the interaction between CD47 and SIRPα in ENKTL need further investigation.

Indexed as

CD47 AntigenLymphoma, Extranodal NK-T-CellReceptors, ImmunologicAdultAgedAntigens, DifferentiationFemaleHumansImmunohistochemistryMaleMiddle AgedPrognosisSurvival RateAntigens, DifferentiationCD47 AntigenCD47 protein, humanReceptors, ImmunologicSIRPA protein, humanCD47ClinicopathologicalExtranodal Natural killer/T-cell lymphomaPrognosticSignal-regulatory protein-alpha

Identifiers

PMID38886192

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