Crafting Stable Antibiotic Nanoparticles via Complex Coacervation of Colistin with Block Copolymers.

Thomas D Vogelaar, Anne E Agger, Janne E Reseland, Dirk Linke, Håvard Jenssen, Reidar Lund

Abstract read

In one paragraph

Article in Biomacromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Coacervation in Slow Motion: Kinetics of Complex Micelle Formation Induced by the Hydrolysis of an Antibiotic Prodrug.Molecular pharmaceutics · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thomas D VogelaarDepartment of Chemistry, University of Oslo, P.O. Box 1033, Blindern, NO-0315 Oslo, Norway.ORCID 0000-0002-1653-1477

Anne E AggerDepartment of Biomaterials, Institute of Clinical Dentistry, University of Oslo, P.O. Box 1109, Blindern, NO-0317 Oslo, Norway.ORCID 0000-0002-9180-1297

Janne E ReselandDepartment of Biomaterials, Institute of Clinical Dentistry, University of Oslo, P.O. Box 1109, Blindern, NO-0317 Oslo, Norway.

Dirk LinkeDepartment of Biosciences, University of Oslo, P.O. Box 1066, Blindern, NO-0316 Oslo, Norway.ORCID 0000-0003-3150-6752

Håvard JenssenDepartment of Science and Environment, Roskilde University, 4000 Roskilde, Denmark.ORCID 0000-0003-0007-0335

Reidar LundDepartment of Chemistry, University of Oslo, P.O. Box 1033, Blindern, NO-0315 Oslo, Norway.ORCID 0000-0001-8017-6396

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To combat the ever-growing increase of multidrug-resistant (MDR) bacteria, action must be taken in the development of antibiotic formulations. Colistin, an effective antibiotic, was found to be nephrotoxic and neurotoxic, consequently leading to a ban on its use in the 1980s. A decade later, colistin use was revived and nowadays used as a last-resort treatment against Gram-negative bacterial infections, although highly regulated. If cytotoxicity issues can be resolved, colistin could be an effective option to combat MDR bacteria. Herein, we investigate the complexation of colistin with poly(ethylene oxide)-

Indexed as

Anti-Bacterial AgentsColistinNanoparticlesHumansMicellesPolyethylene GlycolsPolymethacrylic AcidsAnti-Bacterial AgentsColistinMicellesPolyethylene GlycolsPolymethacrylic Acids

Identifiers

PMID38886154

DOI10.1021/acs.biomac.4c00337

PMCPMC11238337

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.