ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024
A Prelimbic Cortex-Thalamus Circuit Bidirectionally Regulates Innate and Stress-Induced Anxiety-Like Behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Music Therapy Modulates Abnormal Brain Networks and Alleviates Anxiety Symptoms in University Students: An fNIRS Study.Depression and anxiety · 2025Trial
- Progress in pain mechanisms and management.Signal transduction and targeted therapy · 2026Review
- Contributions of dorsal medial prefrontal cortex GABAergic mu opioid receptors on acute restraint stress-induced anxiety-like behavior.Biology direct · 2026Article
- Medium-intensity aerobic exercise can relieve mice anxiety by activating cannabinoid type 1 receptors on medial prefrontal cortex GABAergic neurons.Translational psychiatry · 2026Article
- Activity of VMS-projecting mPFC neurons encodes individual vulnerability to chronic restraint stress in male mice.Neurobiology of stress · 2026Article
- Oxytocin attenuates fear learning via enhancing somatostatin interneuron-mediated local GABAergic inhibition in the prelimbic cortex.Science advances · 2026Article
- Social touch-like tactile stimulation alleviates stress-induced anxiety-like behavior by enhancing the oxytocin level in the prefrontal cortex.Neurobiology of stress · 2026Article
- Neural mechanisms of the V2M-PrL pathway mediate blue light-induced spatial memory impairment.Communications biology · 2025Article
- The association between perceived stress and resilience among medical staff during public health emergencies: mediating effect of self-efficacy.BMC psychology · 2025Article
- Association between anxiety disorder, anxiolytic drugs, and risk of incident Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Exercise-induced PV network plasticity in the prelimbic cortex regulates the expression of fear memory in male mice.Translational psychiatry · 2025Article
- Theta oscillation synchronize VTA and mPFC during ethanol-induced conditioned place preference and stress-evoked anxiety.Translational psychiatry · 2025Article
- An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour.Translational psychiatry · 2025Article
- Gut microbiota regulates innate anxiety through neural activity of medial prefrontal cortex in male mice.Frontiers in neuroscience · 2025Article
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12 authors.
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Abstract
Anxiety-related disorders respond to cognitive behavioral therapies, which involved the medial prefrontal cortex (mPFC). Previous studies have suggested that subregions of the mPFC have different and even opposite roles in regulating innate anxiety. However, the specific causal targets of their descending projections in modulating innate anxiety and stress-induced anxiety have yet to be fully elucidated. Here, we found that among the various downstream pathways of the prelimbic cortex (PL), a subregion of the mPFC, PL-mediodorsal thalamic nucleus (MD) projection, and PL-ventral tegmental area (VTA) projection exhibited antagonistic effects on anxiety-like behavior, while the PL-MD projection but not PL-VTA projection was necessary for the animal to guide anxiety-related behavior. In addition, MD-projecting PL neurons bidirectionally regulated remote but not recent fear memory retrieval. Notably, restraint stress induced high-anxiety state accompanied by strengthening the excitatory inputs onto MD-projecting PL neurons, and inhibiting PL-MD pathway rescued the stress-induced anxiety. Our findings reveal that the activity of PL-MD pathway may be an essential factor to maintain certain level of anxiety, and stress increased the excitability of this pathway, leading to inappropriate emotional expression, and suggests that targeting specific PL circuits may aid the development of therapies for the treatment of stress-related disorders.
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