Evidence map›Paper›PMID 38886057›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Calcineurin and CK2 Reciprocally Regulate Synaptic AMPA Receptor Phenotypes via α2δ-1 in Spinal Excitatory Neurons.

Yuying Huang 黄玉莹, Jian-Ying Shao 邵建英, Hong Chen 陈红, Jing-Jing Zhou 周京京, Shao-Rui Chen 陈少瑞, Hui-Lin Pan 潘惠麟

Erratum issuedAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. HIV-1 gp120 Induces Nociceptive Hypersensitivity via α2δ-1-Bound NMDA Receptors at Primary Afferent→Excitatory Neuron Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. AMPAR Regulation in Synaptic Plasticity: The Roles of Calcineurin, CK2, and α2δ-1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Review
  7. 5Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Yuying Huang 黄玉莹Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Jian-Ying Shao 邵建英Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Hong Chen 陈红Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Jing-Jing Zhou 周京京Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.ORCID 0000-0001-5859-9827
Shao-Rui Chen 陈少瑞Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Hui-Lin Pan 潘惠麟Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.ORCID 0000-0001-8444-3770

Funding

Molecular Determinants of Synaptic Plasticity in Chronic PainR01NS101880 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Shao-Rui Chen, Hui-Lin Pan · 2017 to 2026
$4.1M
Mechanisms of Epigenetic Plasticity in Neuropathic PainR01NS132398 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Shao-Rui Chen, Hui-Lin Pan · 2023 to 2026
$1.8M
NINDS NIH HHS R01 NS101880NINDS NIH HHS R01 NS132398
6 · The paper itself

Abstract

Calcineurin inhibitors, such as cyclosporine and tacrolimus (FK506), are commonly used immunosuppressants for preserving transplanted organs and tissues. However, these drugs can cause severe and persistent pain. GluA2-lacking, calcium-permeable AMPA receptors (CP-AMPARs) are implicated in various neurological disorders, including neuropathic pain. It is unclear whether and how constitutive calcineurin, a Ca

Indexed as

CalcineurinCasein Kinase IIReceptors, AMPASpinal CordTacrolimusAnimalsCalcineurin InhibitorsCalcium ChannelsExcitatory Postsynaptic PotentialsFemaleMaleMiceMice, Inbred C57BLNeuronsPhenotypeSynapsesCACNA2D1 protein, mouseCalcineurinCalcineurin InhibitorsCalcium ChannelsCasein Kinase IIReceptors, AMPATacrolimuscasein kinase 2gabapentinoidinterneuronneuropathic painsynaptic plasticityvesicular inhibitory amino acid transporter (VIAAT)

Identifiers

PMID38886057
PMCPMC11255431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.