Evidence map›Paper›PMID 38885990›Full record

ArticleBMJ open2024

Assessing the effectiveness of artificial intelligence (AI) in prioritising CT head interpretation: study protocol for a stepped-wedge cluster randomised trial (ACCEPT-AI).

Kavitha Vimalesvaran, Dennis Robert, Shamie Kumar, Ayan Kumar, Mariapola Narbone, Rahul Dharmadhikari, Mark Harrison, Sarim Ather, Alex Novak, Mariusz Grzeda and 5 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06027411 (A Mixed Methods Study to Assess the Clinical Effectiveness and Acceptability of qER Artificial Intelligence Software to Prioritise CT Head Interpretation.), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06027411 unknown statusnot on this map

A Mixed Methods Study to Assess the Clinical Effectiveness and Acceptability of qER Artificial Intelligence Software to Prioritise CT Head Interpretation.

Typeobservational_patient_registrySponsorGuy's and St Thomas' NHS Foundation TrustRan2024 to 2024Enrolled16,800ConditionsTrauma, Brain, Mass Lesion, Skull Fractures, Hemorrhage, IntracranialArmsqER (qER EU 2.0)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kavitha VimalesvaranClinical Scientific Computing, Guy's and St Thomas' NHS Foundation Trust, London, UK kavitha.1.vimalesvaran@kcl.ac.uk.ORCID 0000-0003-2236-7279
Dennis RobertQure.AI, Mumbai, India.
Shamie KumarQure.AI, Mumbai, India.
Ayan KumarQure.AI, Mumbai, India.
Mariapola NarboneGuy's and St Thomas' Hospitals NHS Trust, London, UK.
Rahul DharmadhikariNorthumbria Healthcare NHS Foundation Trust, North Shields, UK.
Mark HarrisonNorthumbria Healthcare NHS Foundation Trust, North Shields, UK.
Sarim AtherOxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID 0000-0001-9614-5033
Alex NovakEmergency Medicine Research Oxford (EMROx), Oxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID 0000-0002-5880-8235
Mariusz GrzedaKing's College London, London, UK.
Jane GoochUniversity of Derby, Derby, UK.
Nicholas WoznitzaDepartment of Radiology, Homerton University Hospital NHS Foundation Trust, London, UK.ORCID 0000-0001-9598-189X
Mark HallNHS Greater Glasgow and Clyde, Glasgow, UK.
Haris ShuaibGuy's and St Thomas' NHS Foundation Trust, London, UK.
David J LoweEmergency Medicine, Queen Elizabeth University Hospital, Glasgow, UK.ORCID 0000-0003-4866-2049

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDiagnostic imaging is vital in emergency departments (EDs). Accessibility and reporting impacts ED workflow and patient care. With radiology workforce shortages, reporting capacity is limited, leading to image interpretation delays. Turnaround times for image reporting are an ED bottleneck. Artificial intelligence (AI) algorithms can improve productivity, efficiency and accuracy in diagnostic radiology, contingent on their clinical efficacy. This includes positively impacting patient care and improving clinical workflow. The ACCEPT-AI study will evaluate Qure.ai's qER software in identifying and prioritising patients with critical findings from AI analysis of non-contrast head CT (NCCT) scans. METHODS AND ANALYSIS: This is a multicentre trial, spanning four diverse sites, over 13 months. It will include all individuals above the age of 18 years who present to the ED, referred for an NCCT. The project will be divided into three consecutive phases (pre-implementation, implementation and post-implementation of the qER solution) in a stepped-wedge design to control for adoption bias and adjust for time-based changes in the background patient characteristics. Pre-implementation involves baseline data for standard care to support the primary and secondary outcomes. The implementation phase includes staff training and qER solution threshold adjustments in detecting target abnormalities adjusted, if necessary. The post-implementation phase will introduce a notification (prioritised flag) in the radiology information system. The radiologist can choose to agree with the qER findings or ignore it according to their clinical judgement before writing and signing off the report. Non-qER processed scans will be handled as per standard care. ETHICS AND DISSEMINATION: The study will be conducted in accordance with the principles of Good Clinical Practice. The protocol was approved by the Research Ethics Committee of East Midlands (Leicester Central), in May 2023 (REC (Research Ethics Committee) 23/EM/0108). Results will be published in peer-reviewed journals and disseminated in scientific findings (ClinicalTrials.gov: NCT06027411) TRIAL REGISTRATION NUMBER: NCT06027411.

Indexed as

Artificial IntelligenceEmergency Service, HospitalTomography, X-Ray ComputedAlgorithmsHeadHumansMulticenter Studies as TopicRandomized Controlled Trials as Topicaccident & emergency medicineclinical decision-makingclinical trialdiagnostic imagingstroke

Identifiers

PMID38885990
PMCPMC11184206

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.