Observational studyAnnals of internal medicine2024

Metformin Use in the First Trimester of Pregnancy and Risk for Nonlive Birth and Congenital Malformations: Emulating a Target Trial Using Real-World Data.

What the trial testedas reported · 850 people · 2024

Not counted

+2%+1% to +4%

Smaller than almost all on the map

As reported

RR 1.02, 95% CI 1.01–1.04

Range includes no effect

−28%−49% to +9%

Bigger than 6 in 10 on the map

As reported

RR 0.72, 95% CI 0.51–1.09

the abstract, start to end

… insulin plus metformin (risk ratio, 1.02 [95% CI, 1.01 to 1.04]).

… insulin plus metformin (risk ratio, 0.72 [CI, 0.51 to 1.09]).

← favours treatmentfavours comparator →

could be chance

Pregnancy & neonatal

RR 1.021.01–1.04

Pregnancy & neonatal

RR 0.720.51–1.09

MetforminInsulinPregnancy & neonatal

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