ArticlePLoS pathogens2024
Wolbachia mediates crosstalk between miRNA and Toll pathways to enhance resistance to dengue virus in Aedes aegypti.
Article in PLoS pathogens, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- LncRNA6470/ace-miR-750-y axis modulatesVirulence · 2026Article
- Regulatory mechanisms of nitrogen homeostasis in insect growth and development.Insect science · 2026Review
- Transcriptomic and RNAi-mediated antiviral response to Kamiti River virus infection in Aedes albopictus U4.4 cells.Scientific reports · 2026Article
- Three decades of analyzing Wolbachia bacterial endosymbionts in arthropods: Trends and gaps.Parasitology research · 2026Review
- Wolbachia-driven host miRNAs mediate arthropod reproduction in a Wolbachia density-dependent manner.Communications biology · 2026Article
- The inhibition mechanism ofFrontiers in microbiology · 2026Review
- Article
- Temporal Dynamics of Bacterial Communities inInsects · 2025Article
- Dynamics of vector competence for dengue virus type 2 in rural and urban populations of Aedes albopictus: implications for infectious disease control.Parasites & vectors · 2025Article
- Microsporidian infection of mosquito larvae changes the host-associated microbiome towards the synthesis of antimicrobial factors.Parasites & vectors · 2025Article
- Serine Hydroxymethyltransferase Modulates Midgut Physiology inBiomolecules · 2025Article
- Dual Regulation and Clinical Application of miR-34 in Virus-Related Tumors Through Anti-Viral Immunity and Tumor Suppression.Drug design, development and therapy · 2025Review
- The Japanese encephalitis virus NS1' protein facilitates virus infection in mosquitoes.PLoS neglected tropical diseases · 2025Article
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Authors and funding
14 authors.
Funding
Abstract
The obligate endosymbiont Wolbachia induces pathogen interference in the primary disease vector Aedes aegypti, facilitating the utilization of Wolbachia-based mosquito control for arbovirus prevention, particularly against dengue virus (DENV). However, the mechanisms underlying Wolbachia-mediated virus blockade have not been fully elucidated. Here, we report that Wolbachia activates the host cytoplasmic miRNA biogenesis pathway to suppress DENV infection. Through the suppression of the long noncoding RNA aae-lnc-2268 by Wolbachia wAlbB, aae-miR-34-3p, a miRNA upregulated by the Wolbachia strains wAlbB and wMelPop, promoted the expression of the antiviral effector defensin and cecropin genes through the Toll pathway regulator MyD88. Notably, anti-DENV resistance induced by Wolbachia can be further enhanced, with the potential to achieve complete virus blockade by increasing the expression of aae-miR-34-3p in Ae. aegypti. Furthermore, the downregulation of aae-miR-34-3p compromised Wolbachia-mediated virus blockade. These findings reveal a novel mechanism by which Wolbachia establishes crosstalk between the cytoplasmic miRNA pathway and the Toll pathway via aae-miR-34-3p to strengthen antiviral immune responses against DENV. Our results will aid in the advancement of Wolbachia for arbovirus control by enhancing its virus-blocking efficiency.
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