ArticlePloS one2024
Structural characterization and evaluation of antimicrobial and cytotoxic activity of six plant phenolic acids.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
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- Dietary Plant-Derived Phenolic Acids and Phenolamides as Natural Preservatives: Antibacterial, Antioxidant and Food Preservation Applications.Foods (Basel, Switzerland) · 2026Review
- Antioxidant, pro-oxidant, cytotoxic and antimicrobial properties of selected plant phenolic compounds and resulting structure-activity relationships.Scientific reports · 2026Article
- Isoxanthohumol and Its Derivatives: Antioxidant Activity and Effects on the Gut Microbiota.Molecules (Basel, Switzerland) · 2026Review
- Mn(II) Complex with Rutin-Spectral Characteristic, Quantum-Chemical Calculations, Antioxidant and α-Amylase Inhibitory Activity.Materials (Basel, Switzerland) · 2026Article
- Towards the Development of Effective Antioxidants-The Molecular Structure and Properties-Part 2.Molecules (Basel, Switzerland) · 2026Review
- Metabolome and transcriptome analyses reveal metabolic differences and identify candidate regulatory factors among three habitat types ofFrontiers in plant science · 2026Article
- Polyphenols fromMembranes · 2025Article
- Research Advances in the Synthesis, Metabolism, and Function of Chlorogenic Acid.Foods (Basel, Switzerland) · 2025Review
- Pharmacological Potential and Bioactive Components of Wild Anatolian Sage (Food science & nutrition · 2025Article
- Recent Advances, Challenges, and Functional Applications of Natural Phenolic Compounds in the Meat Products Industry.Antioxidants (Basel, Switzerland) · 2025Review
- Extracts from Wheat, Maize, and Sunflower Waste as Natural Raw Materials for Cosmetics: Value-Added Products Reaching Sustainability Goals.Pharmaceutics · 2024Article
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Authors and funding
9 authors.
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Abstract
Phenolic acids still gain significant attention due to their potential antimicrobial and cytotoxic properties. In this study, we have investigated the antimicrobial of six phenolic acids, namely chlorogenic, caffeic, p-coumaric, rosmarinic, gallic and tannic acids in the concentration range 0.5-500 μM, against Escherichia coli and Lactobacillus rhamnosus. The antimicrobial activity was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay. Additionally, the cytotoxic effects of these phenolic acids on two cancer cell lines, the colorectal adenocarcinoma Caco-2 cell line and Dukes' type C colorectal adenocarcinoma DLD-1 cell line was examined. To further understand the molecular properties of these phenolic acids, quantum chemical calculations were performed using the Gaussian 09W program. Parameters such as ionization potential, electron affinity, electronegativity, chemical hardness, chemical softness, dipole moment, and electrophilicity index were obtained. The lipophilicity properties represented by logP parameter was also discussed. This study provides a comprehensive evaluation of the antimicrobial and cytotoxic activity of six phenolic acids, compounds deliberately selected due to their chemical structure. They are derivatives of benzoic or cinnamic acids with the increasing number of hydroxyl groups in the aromatic ring. The integration of experimental and computational methodologies provides a knowledge of the molecular characteristics of bioactive compounds and partial explanation of the relationship between the molecular structure and biological properties. This knowledge aids in guiding the development of bioactive components for use in dietary supplements, functional foods and pharmaceutical drugs.
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