Evidence map›Paper›PMID 38885176›Full record

ArticleJournal of proteome research2024

Tear Proteins Altered in Patients with Persistent Eye Pain after Refractive Surgery: Biomarker Candidate Discovery.

Brooke M Harkness, Siting Chen, Kilsun Kim, Ashok P Reddy, Trevor J McFarland, Deborah M Hegarty, Steven J Everist, Julie A Saugstad, Jodi Lapidus, Anat Galor and 1 more

Abstract read
In one paragraph

Article in Journal of proteome research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brooke M HarknessCasey Eye Institute, Oregon Health & Science University, Portland, Oregon 97239-4197, United States.ORCID 0000-0003-4787-3469
Siting ChenSchool of Public Health, Oregon Health & Science University-Portland State University, Portland, Oregon 97239-4197, United States.
Kilsun KimProteomics Shared Resource, Oregon Health & Science University, Portland, Oregon 97239-4197, United States.
Ashok P ReddyProteomics Shared Resource, Oregon Health & Science University, Portland, Oregon 97239-4197, United States.
Trevor J McFarlandDepartment of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239-4197, United States.
Deborah M HegartyDepartment of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, Oregon 97239-4197, United States.
Steven J EveristDepartment of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, Oregon 97239-4197, United States.
Julie A SaugstadDepartment of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239-4197, United States.
Jodi LapidusSchool of Public Health, Oregon Health & Science University-Portland State University, Portland, Oregon 97239-4197, United States.
Anat GalorBascom Palmer Eye Institute, University of Miami Health System, Miami, Florida 33146, United States.
Sue A AicherDepartment of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, Oregon 97239-4197, United States.

Funding

Understanding the origins of rapid recurrence of pancreatic cancer after resectionP30CA069533 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Luiz Eduardo Bertassoni · 1997 to 2026
$60.5M
Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI John Peter Campbell · 1995 to 2026
$19.4M
Tear protein biomarkers of refractive surgery painR33EY032468 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A, GALOR, ANAT · 2023 to 2025
$2.9M
Tear protein biomarkers of refractive surgery painR61EY032468 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A, GALOR, ANAT · 2020 to 2022
$2.0M
LTQ Orbitrap VelosS10OD012246 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI DAVID, LARRY L · 2012 to 2012
$854k
LTQ XL Linear Ion Trap Mass SpectrometerS10RR025571 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI DAVID, LARRY L · 2009 to 2009
$389k
NCRR NIH HHS S10 RR025571NEI NIH HHS R33 EY032468NEI NIH HHS R61 EY032468
6 · The paper itself

Abstract

Some patients develop persistent eye pain after refractive surgery, but factors that cause or sustain pain are unknown. We tested whether tear proteins of patients with pain 3 months after surgery differ from those of patients without pain. Patients undergoing refractive surgery (laser in situ keratomileusis or photorefractive keratectomy ) were recruited from 2 clinics, and tears were collected 3 months after surgery. Participants rated their eye pain using a numerical rating scale (NRS, 0-10; no pain-worst pain) at baseline, 1 day, and 3 months after surgery. Using tandem mass tag proteomic analysis, we examined tears from patients with pain [NRS ≥ 3 at 3 months (

Indexed as

BiomarkersEye ProteinsAdultEye PainFemaleHumansKeratomileusis, Laser In SituMaleMiddle AgedPhotorefractive KeratectomyPostoperative PainProteomicsRefractive Surgical ProceduresTandem Mass SpectrometryTearsBiomarkersEye Proteinstear proteinsbiomarkercorneal paineye painLASIKPRKtears

Identifiers

PMID38885176
PMCPMC13225680

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.