Evidence map›Paper›PMID 38884938›Full record

ArticlePharmacogenomics2024

Influence of genetic polymorphisms on pharmacokinetics and treatment response of mycophenolic acid: a scoping review.

Hui-Yin Yow, Muthi Ikawati, Soni Siswanto, Adam Hermawan, Alim Khodimul Rahmat, Janet Sui-Ling Tan, Ying-Chew Tee, Kok-Peng Ng, Zullies Ikawati

Abstract readScoping Review
In one paragraph

Article in Pharmacogenomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hui-Yin YowDepartment of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.ORCID 0000-0002-9455-0817
Muthi IkawatiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Daerah Istimewa Yogyakarta, 55281, Indonesia.ORCID 0000-0002-5968-0130
Soni SiswantoDepartment of Pharmacology & Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Daerah Istimewa Yogyakarta, 55281, Indonesia.ORCID 0000-0003-2525-3584
Adam HermawanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Daerah Istimewa Yogyakarta, 55281, Indonesia.ORCID 0000-0001-5851-3691
Alim Khodimul RahmatDepartment of Pharmacology & Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Daerah Istimewa Yogyakarta, 55281, Indonesia.ORCID 0009-0000-8710-2461
Janet Sui-Ling TanDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.ORCID 0000-0001-5317-466X
Ying-Chew TeeRheumatology Unit, Department of Medicine, University Malaya, Kuala Lumpur, 50603, Malaysia.ORCID 0000-0002-8263-7632
Kok-Peng NgNephrology Unit, Department of Medicine, University Malaya, Kuala Lumpur, 50603, Malaysia.ORCID 0000-0001-7098-4410
Zullies IkawatiDepartment of Pharmacology & Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Daerah Istimewa Yogyakarta, 55281, Indonesia.ORCID 0000-0002-4812-055X

Funding

SATU Joint Research Scheme Program Universiti Malaya International Collaboration Grant ST028-2023SATU JRS Collaboration Research Universitas Gadjah Mada 8778/UN1.P.II/Dit-Lit/PT.01.03/2023
6 · The paper itself

Abstract

This scoping review explores the impact of genetic polymorphisms on the pharmacokinetics and treatment responses of mycophenolic acid (MPA), an immunosuppressant. The study includes 83 articles from 1226 original studies, focusing on transplantation (n = 80) and autoimmune disorders (n = 3). Genetic variants in uridine 5'-diphospho-glucuronosyltransferase (

Indexed as

GlucuronosyltransferaseImmunosuppressive AgentsMultidrug Resistance-Associated Protein 2Mycophenolic AcidAutoimmune DiseasesGraft RejectionHumansIMP DehydrogenasePolymorphism, GeneticUDP-Glucuronosyltransferase 1A9ABCC2 protein, humanGlucuronosyltransferaseImmunosuppressive AgentsIMP DehydrogenaseMultidrug Resistance-Associated Protein 2Mycophenolic AcidUDP-Glucuronosyltransferase 1A9UDP-glucuronosyltransferase, UGT1A8immunosuppressantmycophenolic acidpharmacogenomicspolymorphisms

Identifiers

PMID38884938
PMCPMC11388138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.