Evidence map›Paper›PMID 38884920›Full record

ArticleCardiovascular drugs and therapy2025

Hydrogen Sulfide Ameliorates Heart Aging by Downregulating Matrix Metalloproteinase-9.

Kaichuan He, Huaxing Zhang, Bo Tan, Chengqing Song, Zihui Liang, Lixia Zhang, Danyang Tian, Lin Xiao, Hongmei Xue, Qi Guo and 4 more

Abstract read
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In one paragraph

Article in Cardiovascular drugs and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kaichuan HeDepartment of Physiology, Hebei Medical University, 050017, Hebei, China.
Huaxing ZhangCore Facilities and Centers, Hebei Medical University, 050017, Hebei, China.
Bo TanClinical Pharmacokinetic Laboratory, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, China.
Chengqing SongDepartment of Physiology, Hebei Medical University, 050017, Hebei, China.
Zihui LiangClinical Practice Teaching Department, Hebei Medical University, 050017, Hebei, China.
Lixia ZhangDepartment of Medical Laboratory, Hebei Children's Hospital, 050017, Hebei, China.
Danyang TianDepartment of Physiology, Hebei Medical University, 050017, Hebei, China.
Lin XiaoDepartment of Physiology, Hebei Medical University, 050017, Hebei, China.
Hongmei XueDepartment of Physiology, Hebei Medical University, 050017, Hebei, China.
Qi GuoDepartment of Physiology, Hebei Medical University, 050017, Hebei, China.
Xu TengDepartment of Physiology, Hebei Medical University, 050017, Hebei, China.
Sheng JinDepartment of Physiology, Hebei Medical University, 050017, Hebei, China.
Cuixia AnDepartment of Psychiatry, the First Hospital of Hebei Medical University, 050031, Hebei, China. acxsunny@sina.com.
Yuming WuDepartment of Physiology, Hebei Medical University, 050017, Hebei, China. wuym@hebmu.edu.cn.ORCID 0000-0002-3282-056X

Funding

National Natural Science Foundation of China 32271155, 91849120 and 31871154Natural Science Foundation of Hebei Province C2020206025the University level Graduate Innovation Funding Project of Hebei Medical University in 2023 XCXZZB202303
6 · The paper itself

Abstract

purposeAging contributes significantly to cardiovascular diseases and cardiac dysfunction, leading to the upregulation of matrix metalloproteinase-9 (MMP-9) in the heart and a significant decrease in hydrogen sulfide (H

methodsWe collected plasma from healthy individuals of different ages to determine the relationship between aging and H

resultsH

conclusionH

Indexed as

AgingHydrogen SulfideMatrix Metalloproteinase 9MyocardiumMyocytes, CardiacVentricular Function, LeftAge FactorsAnimalsCystathionine gamma-LyaseDown-RegulationFemaleFibrosisHumansMaleMiceMice, Inbred C57BLCystathionine gamma-LyaseHydrogen SulfideMatrix Metalloproteinase 9MMP9 protein, humanMmp9 protein, mousesodium bisulfideSulfidesAgingCSEHeartHydrogen sulfideMMP-9

Identifiers

PMID38884920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.