Evidence map›Paper›PMID 38884919›Full record

ReviewClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2025

Tumor-treating fields in cancer therapy: advances of cellular and molecular mechanisms.

Tong Xiao, Hao Zheng, Kaiyang Zu, Youjia Yue, Ying Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tong Xiao *School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Hao Zheng *School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Kaiyang ZuSchool of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Youjia YueSchool of Biomedical Engineeringg, Capital Medical University, Beijing, 100069, China.
Ying WangSchool of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. wangying@ccmu.edu.cn.ORCID http://orcid.org/0000-0002-0154-6991

Funding

National Key Research and Development Program of China 2021YFC2400801
6 · The paper itself

Abstract

Tumor-Treating Fields (TTFields) use intermediate-frequency and low-intensity electric fields to inhibit tumor cells. However, their mechanisms are still not well understood. This article reviews their key antitumor mechanisms at the cellular and molecular levels, including inhibition of proliferation, induction of death, disturbance of migration, and activation of the immune system. The multifaceted biological effects in combination with other cancer treatments are also summarized. The deep insight into their mechanism will help develop more potential antitumor treatments.

Indexed as

Electric Stimulation TherapyNeoplasmsApoptosisCell MovementCell ProliferationHumansAlternating electric fieldsCancerMechanismTherapyTumor-treating fields

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.