Evidence map›Paper›PMID 38884867›Full record

ArticleVeterinary research communications2024

Complex neural tube and skeletal malformations, resembling Chiari malformations, in two calves.

Igor Ribeiro Dos Santos, Carolina Buss Brunner, José Tiago Roza de Moraes, Milena Carolina Paz, Éryca Ceolin Lamego, Luan Cleber Henker, Raquel Silva Alves, Renata da Fontoura Budaszewski, Gabrielle Zanettini Tres, Rafael Marques Gomes and 3 more

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Veterinary research communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Igor Ribeiro Dos SantosSetor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre, Rio Grande do Sul (RS), Brazil. igor.ozn@gmail.com.ORCID http://orcid.org/0000-0002-4247-7478
Carolina Buss BrunnerSetor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre, Rio Grande do Sul (RS), Brazil.ORCID http://orcid.org/0000-0002-5484-2751
José Tiago Roza de MoraesSetor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre, Rio Grande do Sul (RS), Brazil.ORCID http://orcid.org/0009-0000-7263-9629
Milena Carolina PazSetor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre, Rio Grande do Sul (RS), Brazil.ORCID http://orcid.org/0000-0003-2690-7033
Éryca Ceolin LamegoSetor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre, Rio Grande do Sul (RS), Brazil.ORCID http://orcid.org/0000-0003-2308-4633
Luan Cleber HenkerSetor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre, Rio Grande do Sul (RS), Brazil.ORCID http://orcid.org/0000-0001-6556-2010
Raquel Silva AlvesLaboratório de Virologia Veterinária, Faculdade de Veterinária, UFRGS, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-8427-584X
Renata da Fontoura BudaszewskiLaboratório de Virologia Veterinária, Faculdade de Veterinária, UFRGS, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-7102-358X
Gabrielle Zanettini TresSetor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre, Rio Grande do Sul (RS), Brazil.ORCID http://orcid.org/0009-0004-1474-5975
Rafael Marques GomesIndependent Bovine Practitioner, Porto Alegre, RS, Brazil.
Ricardo Schmitt FreitasIndependent Bovine Practitioner, Capivari do Sul, RS, Brazil.ORCID http://orcid.org/0009-0002-5510-9233
Cláudio Wageck CanalLaboratório de Virologia Veterinária, Faculdade de Veterinária, UFRGS, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-0621-243X
Saulo Petinatti PavariniSetor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre, Rio Grande do Sul (RS), Brazil.ORCID http://orcid.org/0000-0002-0798-3594

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Rio Grande do Sul (FAPERGS), and Coordenação de Aperfeiçoamento de Pessoal de Ní́vel Superior (CAPES), Brasil Finance code 001
6 · The paper itself

Abstract

Two 1-day-old full-term female calves from different farms located in the Brazilian state of Rio Grande do Sul were unable to stand due to paresis of the pelvic limbs. Both calves had spina bifida on the spinal lumbar segment and were submitted to euthanasia due to poor prognosis. Postmortem examination revealed cerebellar herniation, caudal displacement of the brainstem, rostral deviation of the cranial nerves, caudal extension of occipital lobes, absence of dorsal lamina of lumbar vertebrae with exposed spinal cord, myelodysplasia, kyphosis, segmental spinal agenesis, renal fusion, muscular atrophy, and arthrogryposis. Histology highlighted myelodysplasia (syringomyelia and diplomyelia) and muscular atrophy. The reverse transcription-polymerase chain reactions for ruminant pestivirus were negative. Based on these lesions, the diagnosis of complex neural tube and skeletal malformations was made. A review of previous publications on calves diagnosed with these malformations, originally called Chiari or Arnold-Chiari malformations, revealed a wide range of nervous system and skeletal lesions. These variations amplified the uncertainty regarding whether all cases represent the same disorder and reinforced the importance of reconfiguring the terminology.

Indexed as

Arnold-Chiari MalformationCattle DiseasesAnimalsAnimals, NewbornBrazilCattleFemaleNeural Tube DefectsArnold-Chiari malformationBovineChiari-malformationNervous system malformationNeural tube defect

Identifiers

PMID38884867

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.