Evidence map›Paper›PMID 38884825›Full record

ArticleHead and neck pathology2024

Oral Papillary Squamous Cell Carcinoma and Oral Squamous Cell Carcinoma: A Histopathological and Immunohistochemical Comparative Study.

Esraa Ashraf Mahmoud, Mohsen Kazem Abdellatif, Sarah Ahmed Mohammed Mahmoud

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

3 authors.

Esraa Ashraf MahmoudFaculty of Dentistry, Cairo University and Teaching Assistant at the Oral Pathology Department, October University for Modern Sciences and Arts, Cairo, Egypt. esraa_ashraf@dentistry.cu.edu.eg.ORCID http://orcid.org/0009-0002-0603-348X
Mohsen Kazem AbdellatifOral and Maxillofacial Pathology, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Sarah Ahmed Mohammed MahmoudOral and Maxillofacial Pathology, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of the study is to investigate the immunohistochemical expression of both Alpha smooth muscle actin and Transforming Growth Factor beta and compare their expression in oral papillary squamous cell carcinoma with their expression in different histological grades of oral squamous cell carcinoma. A correlation between these immuno-histochemical expressions and histological findings will then be performed. The research question is "Do the percentages of α-SMA and TGF-β immune-expression in OPSCC differ from that in the conventional OSCC?".

methodsThis will be achieved by collecting archival blocks of oral papillary squamous cell carcinoma and different grades of oral squamous cell carcinoma, staining the specimens with Transforming Growth Factor beta and alpha smooth muscle actin, then measuring the mean staining index of expression in each group and the area percent of both markers.

resultsResults revealed that transforming growth factor beta expression in the epithelium was high in all cases of well-differentiated squamous cell carcinoma, most oral papillary squamous cell carcinoma, and poorly differentiated oral squamous cell carcinoma. On the other hand, different grades of oral squamous cell carcinoma showed a high staining index of alpha smooth muscle actin expression in the stroma. While cases of oral papillary squamous cell carcinoma were either moderate or low-staining.

conclusionsOral papillary squamous cell carcinoma has a favourable prognosis compared to different histological grades, and the prognosis does not depend only on histological grade but also on other prognostic factors.

Indexed as

ActinsBiomarkers, TumorImmunohistochemistryMouth NeoplasmsCarcinoma, Squamous CellFemaleHumansMaleSquamous Cell Carcinoma of Head and NeckTransforming Growth Factor betaACTA2 protein, humanActinsBiomarkers, TumorTransforming Growth Factor betaAlpha smooth muscle actinModerately differentiated squamous cell carcinomaOral papillary squamous cell carcinomaPoorly differentiated squamous cell carcinomaTransforming growth factor betaWell-differentiated squamous cell carcinoma

Identifiers

PMID38884825
PMCPMC11183025

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