Evidence map›Paper›PMID 38884769›Full record

ArticleAdvances in experimental medicine and biology2024

Molecular Pathways and Animal Models of Arrhythmias.

Tyler L Stevens, Sara Coles, Amy C Sturm, Catherine A Hoover, Maegen A Borzok, Peter J Mohler, Mona El Refaey

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tyler L StevensThe Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Sara ColesDivision of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Amy C SturmGenomic Medicine Institute, 23andMe, Sunnyvale, CA, USA.
Catherine A HooverDepartment of Biochemistry, Chemistry, Engineering and Physics, Commonwealth University of Pennsylvania, Mansfield, PA, USA.
Maegen A BorzokDepartment of Biochemistry, Chemistry, Engineering and Physics, Commonwealth University of Pennsylvania, Mansfield, PA, USA.
Peter J MohlerThe Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Mona El RefaeyThe Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA. mona.elrefaey@osumc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arrhythmias account for over 300,000 annual deaths in the United States, and approximately half of all deaths are associated with heart disease. Mechanisms underlying arrhythmia risk are complex; however, work in humans and animal models over the past 25 years has identified a host of molecular pathways linked with both arrhythmia substrates and triggers. This chapter will focus on select arrhythmia pathways solved by linking human clinical and genetic data with animal models.

Indexed as

Arrhythmias, CardiacDisease Models, AnimalAnimalsHumansSignal TransductionACMAction potentialANK2Ankyrin-BArrhythmogenic Cardiomyopathyatrial arrhythmiasBrugada syndromeCalciumCatecholaminergic polymorphic ventricular tachycardiaChannelopathiesCPVTEarly repolarization syndromeERSFKBP12.6HERGKCNE2KCNJ2KCNJ8KCNQ1Long QT syndromeLQTSReentry arrhythmiasRepolarizationRyanodine receptorRYR2SCN5AShort QT syndromeSQTSVentricular arrhythmias

Identifiers

PMID38884769

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.