Evidence map›Paper›PMID 38884701›Full record

ArticleMolecular neurobiology2025

Polypeptide-PNP2 in Corn Cervi Pantotrichum Ameliorates Cognitive Impairment in Alzheimer's Disease Mice by Inhibiting Microglial Cell Activation.

Hongyan Pei, Zhongmie He, Rui Du, Yi Yang, Shasha Wu, Wenyan Li, Jian Sheng, Chenyang Han

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hongyan PeiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.ORCID http://orcid.org/0000-0002-5596-0258
Zhongmie HeCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Rui DuCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
Yi YangDepartment of Pharmacy, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Shasha WuDepartment of Pharmacy, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Wenyan LiDepartment of Pharmacy, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
Jian ShengThe Second Affiliated Hospital of Jiaxing University, Jiaxing, 314001, China.
Chenyang HanThe Second Affiliated Hospital of Jiaxing University, Jiaxing, 314001, China. 691513770@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We isolated a polypeptide PNP2 from Corn Cervi Pantotrichum and investigated its effect and mechanism on cognitive impairment in Alzheimer's disease (AD) mice. Morris water maze was used to assess the degree of cognitive impairment in mice. Histopathological changes were detected by H&E staining; the expressions of inflammatory cytokines were assayed by ELISA. Western blotting was employed to detect the protein expressions. PNP2 could improve cognitive impairment, central inflammatory response, and NLRP3 signaling in AD mice. In vitro experiments revealed that PNP2 could suppress the inflammatory response of microglial cells and reduce the activation of NLRP3 in microglial cells, while MCC950 could antagonize the effects of PNP2. Polypeptide component PNP2 in Corn Cervi Pantotrichum can ameliorate central nervous inflammation and cognitive impairment in AD mice by suppressing NLRP3 signaling.

Indexed as

Alzheimer DiseaseCognitive DysfunctionMicrogliaNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsCytokinesDisease Models, AnimalMaleMiceMice, TransgenicPeptidesSignal TransductionCytokinesNLR Family, Pyrin Domain-Containing 3 ProteinPeptidesAlzheimer’s diseaseCognitive impairmentCorn Cervi Pantotrichum polypeptideNeuroinflammationNLRP3

Identifiers

PMID38884701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.